Étienne-Émile Baulieu

Étienne-Émile Baulieu (  ; 12 ga Disamba 1926 - 30 ga Mayu 2025) ƙwararren masanin kimiyyar halittu ne kuma likitan zuciya na Faransa wanda aka fi sani da bincikensa a fannin hormones na steroid da kuma rawar da suke takawa wajen haihuwa da tsufa . An yi masa lakabi da "uban" maganin zubar da ciki galibi sakamakon aikinsa kan maganin zubar da ciki na RU486 (Mifepristone). Baulieu ya kuma yi aiki don tantance ko dehydroepiandrosterone (DHEA) prohormone ne kuma ko shi da sauran maye gurbin hormones suma suna ƙara tsawon rai ga mutane.

Rayuwar farko da ilimi

An haifi Baulieu Émile Blum ga iyayen Yahudawa a Strasbourg, Faransa, a ranar 12 ga Disamba 1926. Mahaifinsa, wanda ya mutu lokacin da Baulieu ke da shekaru hudu, shi ne Léon Blum, likita kuma kwararre ne na farko a ciwon sukari. Baulieu ya canza sunansa a lokacin yakin duniya na biyu lokacin da iyalinsa suka gudu zuwa yankin da ke kusa da Grenoble kuma ya shiga cikin juriyar Faransa. Bayan yakin, ya halarci Faculté de Médecine de Paris kuma ya zama likita a shekarar 1955. Ya ci gaba da karatu a karkashin jagorancinsa Max Fernand Jayle (1913-1978 ) a fagen hormones na steroid kuma ya sami digirinsa na PhD a 1963 a Faculté de Médecine da Faculté des Sciences a Paris

Sana'a

A shekarar 1963, an nada Baulieu a matsayin darektan bincike (daidai da cikakken farfesa na bincike) a INSERM, kuma a shekarar 1970 ya zama farfesa a fannin Biochemistry a Faculty of Medicine of Bicêtre, wanda ke da alaƙa da Jami'ar Paris -South. Tun daga shekarar 2004, Baulieu memba ne na "Kwamitin Ba da Shawara kan Ɗabi'a" na Faransa ( Comité Consultatif National d'Ethique ) don kimiyya da lafiya. Haka kuma yana da alaƙa da "Cibiyar Tsawon Rai da Tsufa" (L'Institut de la longévité, des vieillesses et du vieillissement). A shekarar 2008, ya fara Institut Baulieu, wani shirin bincike don nazari da magance cututtukan jijiyoyi, da kuma haɓaka bincike kan tsawon rai mai kyau.

Bincike

Baulieu yana da sha'awar dehydroepiandrosterone (DHEA). A shekarar 1960 ya nuna cewa DHEA ita ce babban sinadarin androgen na adrenal, wanda aka haɗa shi da sinadarin hydrophilic sulfate, kuma ya bayyana yadda yake aiki da kuma ayyukansa. Ya yi aiki don gano samar da estrogens ta hanyar mahaifa yayin daukar ciki kuma wannan ya haifar da ra'ayin cewa DHEA " prohormone " ne. Bayan gayyatar Seymour Lieberman, [1] Baulieu ya zama masanin kimiyya mai ziyara a Jami'ar Columbia a 1961-1962, kuma a wannan lokacin ya haɗu da Gregory Pincus, mahaifin " kwayar hana haihuwa ". [2] Daga nan Baulieu ya koma ga ƙarin bincike kan hana haihuwa da kuma daidaita haihuwa da ciki. Ya zama majagaba a cikin bayanin masu karɓar steroid na jima'i a cikin ƙwayoyin halitta kuma ya gano manyan mahalarta cikin ƙwayoyin halitta kamar sunadaran girgizar zafi . Ya yi aiki akan mai karɓar progesterone da mai karɓar androgen . Duk da cewa galibi ana samun masu karɓar steroid a cikin ƙwayoyin halitta, Baulieu ya gano mai karɓar membrane don hormone steroid a cikin Xenopus laevis .

Mutuwa

Baulieu ya mutu a gidansa da ke Paris, a ranar 30 ga Mayu 2025, yana da shekaru 98.