Abinci mai nauyi
 Abinci mai nauyi | |
|---|---|
| Bayanai | |
| Ƙaramin ɓangare na |
diet (en)  |
Abinci mai nauyi shine amfani da abubuwan gina jiki wanda aka maye gurbin wasu atoms tare da isotopes masu nauyi marasa rediyo, kamar (2H) ko (13C). Biomolecules waɗanda suka haɗa da isotopes masu nauyi suna haifar da tsarin kwayoyin da ya fi tsayayya a wasu yanayi, wanda aka yi la'akari da ƙara juriya ga lalacewar da ke da alaƙa da tsufa [1] ko cututtuka. [2][3]
Magunguna tare da wasu ƙwayoyin hydrogen da aka maye gurbin da deuterium ana kiransu magungunan deuterated, yayin da abubuwa masu mahimmanci za a iya amfani da su azaman kayan abinci, suna sa wannan abinci "isotopic". Idan aka ci tare da abinci, waɗannan abubuwan gina jiki sun zama kayan gini ga jiki. Misalan sune deuterated polyunsaturated fatty acids, aminoacids masu mahimmanci, [4] tushen DNA kamar cytosine, [5] ko Ruwa mai nauyi da glucose. [6]
Hanyar da aka ba da shawarar
[gyara sashe | gyara masomin]Ɗaya daga cikin mafi muni da kuma ba za a iya gyarawa ba na Lalacewar oxidative da aka haifar da nau'in oxygen mai amsawa (ROS) a kan kwayoyin halitta ya haɗa da rarraba haɗin carbon-hydrogen (abstraction hydrogen). Abin sha'awa, kwayoyin halitta da suka fi lalacewa ta wannan nau'in lalacewa suna cikin ƙungiyar Abubuwan gina jiki masu mahimmanci (10 daga cikin amino acid 20; nucleosides a wasu yanayi (yana da mahimmanci); duk polyunsaturated fatty acids). A ka'idar, maye gurbin hydrogen da deuterium "karfafa" haɗin saboda tasirin isotope na kinetic, kuma irin waɗannan ƙwayoyin halitta da jiki ya ɗauka za su fi tsayayya da ROS.[7]
Deuterated omega-6 fatty acids ga mutane tare da cututtukan lalacewa
[gyara sashe | gyara masomin]Kamfanin Retrotope ya fara ci gaba da tushen deuterated Omega-6 fatty acid di-deuterated linoleic acid ethyl ester (RT001) a matsayin kayan abinci don yiwuwar maganin cututtukan neurodegenerative kamar Friedreich's ataxia da yara neuroaxonal dystrophy. FDA ta ba shi sunan maganin marayu kuma ya wuce gwajin asibiti na Mataki na I / II (kamar na 2018). [8]
Dubi kuma
[gyara sashe | gyara masomin]- Magunguna masu guba
- Ruwa mai nauyi
- RT001
Manazarta
[gyara sashe | gyara masomin]- ↑ "Heavy hydrogen keeps yeast looking good".
- ↑ Tsikas, Dimitrios (2017). "Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first". Atherosclerosis. 264: 79–82. doi:10.1016/j.atherosclerosis.2017.07.018. PMID 28756876.
- ↑ "Deuterium diet". Chemistry & Industry. 84 (9): 30–33. 2020. doi:10.1002/cind.849_7.x. S2CID 240909784 Check
|s2cid=value (help). - ↑ Korneenko, Tatyana V; Pestov, Nikolay B; Hurski, Alaksiej L; Fedarkevich, Artsiom M; Shmanai, Vadim V; Brenna, J. Thomas; Shchepinov, Mikhail S (2017). "A strong developmental isotope effect in Caenorhabditis elegans induced by 5,5-deuterated lysine". Amino Acids. 49 (5): 887–894. doi:10.1007/s00726-017-2386-5. PMID 28161800. S2CID 625937.
- ↑ Woodcock, Clayton B; Ulashchik, Egor A; Poopeiko, Nikolai E; Shmanai, Vadim V; Reich, Norbert O; Shchepinov, Mikhail S (2016). "Rational Manipulation of DNA Methylation by Using Isotopically Reinforced Cytosine". ChemBioChem. 17 (21): 2018–2021. doi:10.1002/cbic.201600393. PMID 27595234. S2CID 19507501.
- ↑ Li, Xiyan; Snyder, Michael P (2016). "Yeast longevity promoted by reversing aging-associated decline in heavy isotope content". npj Aging and Mechanisms of Disease. 2: 16004. doi:10.1038/npjamd.2016.4. PMC 5515009. PMID 28721263.
- ↑ Shchepinov, Mikhail S (2007). "Reactive Oxygen Species, Isotope Effect, Essential Nutrients, and Enhanced Longevity". Rejuvenation Research. 10 (1): 47–59. doi:10.1089/rej.2006.0506. PMID 17378752.
- ↑ Schmidt, Charles (2017). "First deuterated drug approved". Nature Biotechnology. 35 (6): 493–494. doi:10.1038/nbt0617-493. PMID 28591114. S2CID 205269152.