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Abubuwan gina jiki

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Abubuwan gina jiki

Epigenetics na gina jiki kimiyya ce da ke nazarin tasirin abinci mai gina jiki akan maganganun kwayoyin halitta da samun damar chromatin . [1] Sashe ne na nau'ikan kwayoyin halitta masu gina jiki wanda ke mai da hankali kan tasirin abubuwan abinci masu rai akan abubuwan da suka faru na epigenetic . [2]

Tarihi

[gyara sashe | gyara masomin]

Canje-canje ga bayanan kwayoyin halittar yara da ke haifar da abinci mai gina jiki na tayin an lura da su tun farkon yunwar Dutch na 1944-1945 . [3] [4] [5] [6] [7] Saboda rashin abinci mai gina jiki a cikin iyaye mata masu juna biyu, yaran da aka haifa a lokacin wannan yunwa sun fi dacewa su nuna al'amuran lafiya kamar cututtukan zuciya, kiba, schizophrenia, damuwa, da jaraba. [3] [4] [5]

Masana ilimin halittu Randy Jirtle da Robert A. Waterland sun zama farkon majagaba na epigenetics na abinci mai gina jiki bayan sun buga binciken su game da tasirin abincin uwa mai ciki akan ayyukan halittar 'ya'yanta a cikin mujallar bincike Molecular and Cellular Biology a 2003. [8]

Bincike

[gyara sashe | gyara masomin]

Masu bincike a cikin epigenetics masu gina jiki suna nazarin hulɗar tsakanin kwayoyin halitta a cikin abinci da kwayoyin da ke sarrafa maganganun kwayoyin halitta, wanda ke kaiwa ga wuraren da aka fi mayar da hankali kamar kungiyoyin methyl na abinci da DNA methylation . [8] [9] [10] Abubuwan gina jiki da abubuwan abinci na bioactive suna shafar epigenetics ta hanyar hana ayyukan enzymatic da suka danganci DNA methylation da gyare-gyaren histone . [11] Saboda ana amfani da ƙungiyoyin methyl don murkushe ƙwayoyin halittar da ba a so, matakin uwa na cin abinci na methyl na iya canza yanayin bayyanar ɗanta sosai, musamman lokacin haɓakawa da wuri. [12] Bugu da ƙari kuma, abinci mai gina jiki zai iya rinjayar methylation yayin da tsarin ya ci gaba a cikin rayuwar mutum ta girma. Saboda haka, masu ilimin halitta masu gina jiki sun yi nazarin abinci a matsayin nau'i na bayyanar kwayoyin halitta. [13]

Manazarta

[gyara sashe | gyara masomin]
  1. ↑ Landecker H (June 2011). "Food as exposure: Nutritional epigenetics and the new metabolism". BioSocieties. 6 (2): 167–194. doi:10.1057/biosoc.2011.1. PMC 3500842. PMID 23227106.
  2. ↑ Farhud D, Zarif Yeganeh M, Zarif Yeganeh M (2010). "Nutrigenomics and nutrigenetics". Iranian Journal of Public Health. 39 (4): 1–14. PMC 3481686. PMID 23113033.
  3. ↑ 3.0 3.1 Roseboom TJ, Painter RC, van Abeelen AF, Veenendaal MV, de Rooij SR (October 2011). "Hungry in the womb: what are the consequences? Lessons from the Dutch famine". Maturitas. 70 (2): 141–145. doi:10.1016/j.maturitas.2011.06.017. PMID 21802226.
  4. ↑ 4.0 4.1 Franzek EJ, Sprangers N, Janssens AC, Van Duijn CM, Van De Wetering BJ (March 2008). "Prenatal exposure to the 1944-45 Dutch 'hunger winter' and addiction later in life". Addiction. 103 (3): 433–438. doi:10.1111/j.1360-0443.2007.02084.x. PMID 18190668.
  5. ↑ 5.0 5.1 Painter RC, Roseboom TJ, Bleker OP (2005). "Prenatal exposure to the Dutch famine and disease in later life: an overview". Reproductive Toxicology. 20 (3): 345–352. Bibcode:2005RepTx..20..345P. doi:10.1016/j.reprotox.2005.04.005. PMID 15893910.
  6. ↑ Tiffon, Céline (2018-11-01). "The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease". International Journal of Molecular Sciences (in Turanci). 19 (11): 3425. doi:10.3390/ijms19113425. ISSN 1422-0067. PMC 6275017. PMID 30388784.
  7. ↑ Liu HY, Liu SM, Zhang YZ (April 2020). "Maternal Folic Acid Supplementation Mediates Offspring Health via DNA Methylation". Reproductive Sciences. 27 (4): 963–976. doi:10.1007/s43032-020-00161-2. PMID 32124397. S2CID 211729425.
  8. ↑ 8.0 8.1 Waterland RA, Jirtle RL (August 2003). "Transposable elements: targets for early nutritional effects on epigenetic gene regulation". Molecular and Cellular Biology. 23 (15): 5293–5300. doi:10.1128/MCB.23.15.5293-5300.2003. PMC 165709. PMID 12861015.
  9. ↑ "Nutrigenomics 101: Understanding the Basics of DNA Diets". Gene Food (in Turanci). 2020-02-04. Retrieved 2023-04-20.
  10. ↑ Mazzio EA, Soliman KF (July 2014). "Epigenetics and nutritional environmental signals". Integrative and Comparative Biology. 54 (1): 21–30. doi:10.1093/icb/icu049. PMC 4072902. PMID 24861811.
  11. ↑ Choi SW, Friso S (November 2010). "Epigenetics: A New Bridge between Nutrition and Health". Advances in Nutrition. 1 (1): 8–16. doi:10.3945/an.110.1004. PMC 3042783. PMID 22043447.
  12. ↑ "Nutrition & the Epigenome". Genetic Science Learning Center. University of Utah Genetics. 15 July 2013. Retrieved 2023-04-20.
  13. ↑ Landecker H (June 2011). "Food as exposure: Nutritional epigenetics and the new metabolism". BioSocieties. 6 (2): 167–194. doi:10.1057/biosoc.2011.1. PMC 3500842. PMID 23227106.
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