Bettie Sue Masters

Bettie Sue Masters
Rayuwa
Haihuwa	Lexington (en) ,
ƙasa	Tarayyar Amurka
Karatu
Makaranta	Duke University (en)
Sana'a
Sana'a	biochemist (en)

Bettie Sue Siler Masters farfesa ce a Jami'ar Duke da aka sani da aikinta a kan nitric oxide synthase da cytochrome P450 reductase . Ta kasance mai karɓar lambar yabo ta FASEB Excellence in Science Award a shekarar 1992, kuma an zabe ta a matsayin memba na Kwalejin Kiwon Lafiya ta Kasa kuma a matsayin ɗan ƙungiyar Ƙungiyar Amurka don Ci gaban Kimiyya.

Rayuwa ta farko da ilimi

An haifi Masters a Lexington, Virginia, inda mahaifinta ya kasance mai ba da labari a rediyo kuma mawaƙi. Yayinda take yarinya ta kasance mai son karanta Sherlock Holmes da Dr. Watson wanda ta yi sha'awar kwarewar nazari. Ta zama mai sha'awar ilmin sunadarai a lokacin da take karatun sakandare, kuma ta sanya ta sosai a cikin Binciken Kimiyyar Kimiyya na Westinghouse don karɓar tallafin karatu don kwaleji. Bayan Kwalejin William & Mary ba za ta yarda da tallafin ba saboda ita mace ce, sai ta ci gaba da halartar Kwalejin Roanoke, don haka ta zama ɗalibar kwaleji ta ƙarni na farko. Ta kammala karatu daga Kwalejin Roanoke a 1959 tare da BS a cikin ilmin sunadarai. A shekara ta 1963, ta sami Ph.D. a fannin ilmin sunadarai daga Jami'ar Duke .

Ayyuka

Bayan aikinta na Ph.D., ta gudanar da bincike na postdoctoral da farko tare da tallafin zumunci daga American Cancer Society sannan tare da tallafi daga American Heart Association . A shekara ta 1968, ta koma Jami'ar Texas Southwestern Medical School inda ta fara dakin bincike. A shekara ta 1982, ta koma Kwalejin Kiwon Lafiya ta Wisconsin don karɓar matsayin shugaban sashen ilmin sunadarai, don haka ta zama mace ta farko da ta riƙe wannan matsayi. A shekara ta 1990, ta koma Cibiyar Kimiyya ta Lafiya ta Jami'ar Texas a San Antonio inda aka sanya mata suna a matsayin Farfesa mai daraja a fannin ilmin sunadarai. Ya zuwa 2022, ta kasance farfesa a Jami'ar Duke a sashen ilmin sunadarai.

Bincike

An san Masters da aikinta a kan tsari da aikin enzymes. A matsayinta na dalibi mai digiri ta nuna cytochrome P450 reductase (NADPH-cytochrome P450, oxidoreductase). Ta ci gaba da haɓaka hanyoyin tsarkake enzymes, kamar cytochrome P450 reductase, wanda ke ba da damar bincike game da kaddarorin su na biochemical da kuma gano wuraren aiki na furotin ta hanyar x-ray crystallography. Game da nitric oxide synthase, ta bincika tsarin atom na endothelial isoenzyme, da zinc da aka ɗaure a cikin furotin, da kuma abubuwan haɗin gwiwar da ake buƙata (heme da tetrahydrobiopterin).

Littattafan da aka zaɓa

• Vásquez-Vivar, Jeannette; Kalyanaraman, B.; Martásek, Pavel; Hogg, Neil; Masters, Bettie Sue Siler; Karoui, Hakim; Tordo, Paul; Pritchard, Kirkwood A. (1998-08-04). "Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors". Proceedings of the National Academy of Sciences (in Turanci). 95 (16): 9220–9225. Bibcode:1998PNAS...95.9220V. doi:10.1073/pnas.95.16.9220. ISSN 0027-8424. PMC 21319. PMID 9689061.
• Roman, L J; Sheta, E A; Martasek, P; Gross, S S; Liu, Q; Masters, B S (1995-08-29). "High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli". Proceedings of the National Academy of Sciences (in Turanci). 92 (18): 8428–8432. Bibcode:1995PNAS...92.8428R. doi:10.1073/pnas.92.18.8428. ISSN 0027-8424. PMC 41170. PMID 7545302.
• McMillan, K; Bredt, D S; Hirsch, D J; Snyder, S H; Clark, J E; Masters, B S (1992). "Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide". Proceedings of the National Academy of Sciences (in Turanci). 89 (23): 11141–11145. Bibcode:1992PNAS...8911141M. doi:10.1073/pnas.89.23.11141. ISSN 0027-8424. PMC 50505. PMID 1280819.
• Yasukochi, Y; Masters, B S (1976). "Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography". Journal of Biological Chemistry. 251 (17): 5337–5344. doi:10.1016/s0021-9258(17)33166-6. ISSN 0021-9258. PMID 821951.

Masters ta sami girmamawa da kyaututtuka da yawa daga Kwalejin Roanoke, alma mater dinta. A shekara ta 1973, an ba ta lambar yabo ta Roanoke College Medal saboda rawar da ta yi wa al'ummarta da sana'arta. A shekara ta 1983, ta sami digiri na Doctor of Science daga Kwalejin Roanoke .

A cikin 1990, an dauki Masters a Cibiyar Kimiyya ta Lafiya ta Jami'ar Texas a San Antonio a matsayin Farfesa na farko na Robert A. Welch a cikin ilmin sunadarai. A shekara ta 1992, Masters ya sami Kyautar Kyauta a Kimiyya daga Tarayyar Ƙungiyoyin Amirka don Nazarin Biology (FASEB). A shekara ta 2000, ta kasance mai karɓar lambar yabo ta Bernard B. Brodie a cikin Magungunan Magunguna daga American Society for Pharmacology and Experimental Therapeutics . A shekara ta 1996, an zabi Masters a matsayin memba na Kwalejin Kiwon Lafiya ta Kasa kuma, a shekara ta 2001, an zabe ta a matsayin abokiyar Ƙungiyar Amurka don Ci gaban Kimiyya . [1] A shekara ta 2005, Jami'ar Charles (Prague) ta ba da Masters digiri na girmamawa, Doctorem Medicinae Honoris Causae, don nuna godiya ga aikinta. A cikin 2022, Kwalejin Kiwon Lafiya ta Wisconsin (MCW) ta ba Masters lambar yabo ta Doctor of Science don nuna godiya ga rawar da ta taka a fannin ilmin sunadarai da kuma gudummawar da ta bayar ga horar da masanin kimiyyar likita (ta hanyar fara shirin horar da MCW na MD / PhD - Shirin Horar da Masanin Kimiyya na Kiwon Lafiya).