Diethylcarbamazine
 Diethylcarbamazine | |
|---|---|
type of chemical entity (en)  | |
| Bayanai | |
| Ƙaramin ɓangare na | chemical compound (en) |
| Amfani | magani da filaricide (en) |
| Sinadaran dabara | C₁₀H₂₁N₃O |
| Canonical SMILES (en) | CCN(CC)C(=O)N1CCN(CC1)C |
| Subject has role (en) | 5-lipoxygenase inhibitor (en) da WHO essential medicines (en) |
Diethylcarbamazine magani ne da ake amfani da shi wajen magance Filariasis ciki har da filariasis na lymphatic, eosinophilia na huhu na wurare masu zafi, da loiasis . [1] Hakanan ana iya amfani dashi don rigakafin loiasis a cikin waɗanda ke cikin haɗari mai girma.[1] Duk da yake an yi amfani da shi don onchocerciasis (makantar kogi), an fi son ivermectin. Ana shan shi ta baki.[2]
Sakamakon cututtuka na yau da kullun sun haɗa da ƙishirwa, kumburi na fuska, ciwon kai, da jin gajiya.[1] Sauran tasirin illa sun haɗa da asarar gani da mamaki.[1] Magani ne da aka ba da shawarar a ciki ciki kuma yana da aminci ga jariri.[2][3] Hukumar Lafiya ta Duniya; duk da haka, ta ba da shawarar jira har sai bayan daukar ciki don magani idan ya yiwu.[4] An yi shi ne daga 4-methyl-piperazine.[5]
Diethylcarbamazine an gano shi ne a cikin 1947 ta hanyar Yellapragada Subbarow. [3][4] Yana cikin Jerin Magunguna Masu Muhimmanci na Hukumar Lafiya ta Duniya. Ba a samun sa a kasuwanci a Amurka amma ana iya samun sa daga Cibiyoyin Kula da Cututtuka da Rigakafin Cututtuka.[1]
Amfani ga Lafiya
[gyara sashe | gyara masomin]Ana nuna Diethylcarbamazine don maganin mutanen da ke da wasu cututtukan filarial, gami da lymphatic filariasis wanda kamuwa da cuta ta hanyar Wuchereria bancrofti, Brugia malayi, ko Brugia timori ke haifarwa; loiasis da eosinophilia na huhu na wurare masu zafi.[1] WHO ta ba da shawarar rubuta diethylcarbamazine ga mutanen da suka kamu da microfilariae na ƙwayoyin cuta na filarial da kuma don sarrafa yaɗuwar kamuwa da cuta a yankunan da filariasis ke yaɗuwa. [ana buƙatar hujja][citation needed]
A Indiya da China, an kara diethylcarbamazine zuwa gishiri don yaki da filariasis na lymphatic.[5]
Abinda ke hanawa
[gyara sashe | gyara masomin]Contraindications are previous history of heart problems, gastrointestinal problems, and allergies. [<span title="Material near this tag needs references to reliable medical sources. (September 2015)">medical citation needed</span>]
Hanyar aiki
[gyara sashe | gyara masomin]Diethylcarbamazine mai hana metabolism na Arachidonic acid ne a cikin microfilariae . Wannan ya sa microfilariae ya fi saukin kamuwa da cutar rigakafi, amma ba ya kashe kwayar cuta kai tsaye.[6]
Al'umma da al'adu
[gyara sashe | gyara masomin]Sunayen alama
[gyara sashe | gyara masomin]Sunayen samfuran sun haɗa da Hetrazan, Carbilazine, Caricide, Cypip, Ethodryl, Notézine, Spatonin, Filaribits, Banocide Forte, da Eofil.
Manazarta
[gyara sashe | gyara masomin]- 1 2 3 "Our Formulary Infectious Diseases Laboratories CDC". www.cdc.gov. 22 September 2016. Archived from the original on 16 December 2016. Retrieved 7 December 2016.
- ↑ "Diethylcarbamazine Advanced Patient Information - Drugs.com". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
- ↑ Hewitt R, Wallace W (June 1948). "The treatment of ascariasis in dogs with 1-diethylcarbamyl-4-methylpiperazine hydrochloride". The Journal of Parasitology. 34 (3): 237–239. doi:10.2307/3273270. JSTOR 3273270. PMID 18867399. S2CID 43592055.
- ↑ Kamath P, Shenoy KA (2013). "Yellapragada Subba Rao: The Unsung Hero". Muller Journal of Medical Sciences and Research. 4 (2): 130–132. doi:10.4103/0975-9727.118248. S2CID 72843672. Archived from the original on 2023-04-15. Retrieved 2026-06-13.
- ↑ Lammie P, Milner T, Houston R (July 2007). "Unfulfilled potential: using diethylcarbamazine-fortified salt to eliminate lymphatic filariasis". Bulletin of the World Health Organization. 85 (7): 545–549. doi:10.2471/blt.06.034108. PMC 2636360. PMID 17768503.
- ↑ El-Shahawi GA, Abdel-Latif M, Saad AH, Bahgat M (December 2010). "Setaria equina: in vivo effect of diethylcarbamazine citrate on microfilariae in albino rats". Experimental Parasitology. 126 (4): 603–610. doi:10.1016/j.exppara.2010.06.022. PMID 20599991.