Harry Schachter
 Harry Schachter | |
|---|---|
 | |
| Rayuwa | |
| Haihuwa | 25 ga Faburairu, 1933 |
| ƙasa | Kanada |
| Mutuwa | 17 ga Afirilu, 2024 |
| Karatu | |
| Makaranta |
University of Toronto (en)  Saint Mary's College (en) |
| Sana'a | |
| Sana'a |
biochemist (en) da researcher (en) |
| Employers |
University of Toronto (en) |
| Kyaututtuka | |
Harry Schachter FRSC (25 Fabrairu 1933 - 17 Afrilu 2024) Masanin kimiyyar halittu ne na Kanada kuma masanin ilimin halittu. Ya kasance farfesa a Toronto" id="mwDQ" rel="mw:WikiLink" title="University of Toronto">Jami'ar Toronto da kuma Asibitin Yara Marasa Lafiya a Toronto.
Tarihin rayuwa
[gyara sashe | gyara masomin]An haifi Harry Schachter a Vienna, Austria a 1933. Iyayensa sune Miriam Freund, 'yar kasuwa, da Ulrich Schachter, likitan hakora da likita. Mahaifin Harry dan uwan Austro-Hungarian ne kuma dan wasan kwaikwayo na Romania, Joseph Schmidt . Iyalin Schachter sun tsere daga Nazis a 1938, suna tserewa zuwa Port of Spain, Trinidad . Ya halarci makarantar sakandare a Kwalejin Saint Mary. Ya zo na farko a Trinidad a cikin Cambridge Advanced Level Examinations kuma ya lashe Jerningham Gold Medal da Island Scholarship a cikin Lissafi. Ya kuma yi aiki na ɗan lokaci a matsayin mai ba da rahoto ga jaridar Guardian ta gida. Iyalinsa sun yi hijira zuwa Toronto, Kanada a shekarar 1951.
Ilimi da aiki
[gyara sashe | gyara masomin]A Jami'ar Toronto, Schachter ya kammala BA a fannin ilimin lissafi da ilmin sunadarai a shekarar 1955, MD dinsa a shekarar 1959, da PhD dinsa a fannin ilmin sunayyakin halittu (Gordon Dixon, mai kula) a shekarar 1964. Bayan kammala karatunsa na PhD, an nada shi mataimakin farfesa a Sashen Biochemistry. Ya yi aikinsa na post-doctoral a Glycobiology tare da Saul Roseman a Jami'ar Johns Hopkins daga 1966 zuwa 1968. Ya koma Jami'ar Toronto a shekarar 1968, inda ya kafa dakin gwaje-gwaje a Sashen Biochemistry.
A shekara ta 1976, Schachter ya dauki matsayi a cikin Sashen Binciken Biochemistry a Asibitin Yara Marasa Lafiya, wanda ya jagoranci shekaru 13. Daga 1984 zuwa 1989, ya kasance shugaban Sashen Biochemistry a Jami'ar Toronto.
Gudummawar da ya bayar a fagen kimiyyar carbohydrate sun hada da ganowa da kuma nuna alamun glycosyltransferases 12 da ke cikin kira na N- da O-linked glycans, don haka ya bayyana matakai masu mahimmanci don samar da oligosaccharides a kan glycoproteins waɗanda suka haɗa da masu karɓar sel da sunadarai masu ɓoye. [1][2] Schachter ya kuma taimaka wajen bayyana cutar Carbohydrate-Deficient Glycoprotein Syndrome ta farko (CDG-IIa; yanzu an san shi da cututtukan haihuwa na Glycosylation). [3] Ya taimaka wajen nuna cewa GnTII" id="mwQQ" rel="mw:WikiLink" title="GnTII">GnTII null mice sune kyawawan samfuran CDG-IIa na ɗan adam.[4] Sauran aiki a kan beraye da suka shafi maye gurbi a cikin GnTI, GnTII da GnTIII sun kafa muhimmancin N-glycans a cikin ci gaban metazoan.[5][6] Bugu da ƙari, Schachter ya bincika ayyukan halittu na carbohydrates masu rikitarwa a cikin ci gaban kwakwalwar Drosophila wanda ya nuna takamaiman rawar da aka taka a cikin tsarin siginar insulin da tsawon rayuwa.[7] Ayyukansa na fassara / asibiti sun haɗa da binciken enzymatic a cikin cututtukan ƙwaƙwalwa masu rikitarwa (misali congenital muscular dystrophy) da ke da alaƙa da O-glycosylation mara kyau.[8] Ya wallafa takardun kimiyya sama da 160, sake dubawa, da sharhi.
Schachter ya yi aiki a matsayin mai kula da post-doctoral da kuma mai ba da shawara ga masana kimiyya a cikin dakin gwaje-gwaje, kuma ya haɗa kai da waɗannan da sauran masana kimiyya a Kanada, Turai, Japan, Australia da Amurka. Abokan aiki sun hada da David Williams, Inka Brockhausen, Clifford Lingwood, Mohan Sarkar, Pamela Stanley, Noam Harpaz, Louis Siminovitch, Jeremy Carver, Hudson Freeze, Jaak Jaeken, Jamey Marth, Hans Vliegenthart, Vernon Reinhold, Reinhart Reithmeier, Kevin Campbell, Gabrielle Boulianne, Paul Gleeson, Richard Simpson, Jenny Tan, Andrew Spence, Folkert Reck, Vajsar, Saroja Narasimhan, (RK) Murray, GD, Benmore.
Manazarta
[gyara sashe | gyara masomin]- ↑ Empty citation (help)
- ↑ Empty citation (help)
- ↑ Tan, J; Dunn, J; Jaeken, J; Schachter, H (October 1996). "Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development". Am. J. Hum. Genet. 59 (4): 810–7. PMC 1914797. PMID 8808595.
- ↑ Wang, Y; Tan, J; Sutton-Smith, M; Ditto, D; Panico, M; Campbell, RM; Varki, NM; Long, JM; Jaeken, J; Levinson, SR; Wynshaw-Boris, A; Morris, HR; Le, D; Dell, A; Schachter, H (2001). "Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis". Glycobiology. 11 (12): 1051–70. doi:10.1093/glycob/11.12.1051. PMID 11805078.
- ↑ Metzler, M; Gertz, A; Sarkar, M; Schachter, H; Schrader, JW; Marth, JD (1994). "Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development". EMBO J. 13 (9): 2056–65. doi:10.1002/j.1460-2075.1994.tb06480.x. PMC 395055. PMID 8187759.
- ↑ Priatel, JJ; Sarkar, M; Schachter, H; Marth, JD (1997). "Isolation, characterization and inactivation of the mouse Mgat3 gene: the bisecting N-acetylglucosamine in asparagine-linked oligosaccharides appears dispensable for viability and reproduction". Glycobiology. 7 (1): 45–56. doi:10.1093/glycob/7.1.45. PMID 9061364.
- ↑ Sarkar, M; Leventis, PA; Silvescu, CI; Reinhold, VN; Schachter, H; Boulianne, GL (2006). "Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span". J Biol Chem. 281 (18): 12776–85. doi:10.1074/jbc.M512769200. PMID 16522637.
- ↑ Willer, T; Lee, H; Lommel, M; Yoshida-Moriguchi, T; de Bernabe, DB; Venzke, D; Cirak, S; Schachter, H; Vajsar, J; Voit, T; Muntoni, F; Loder, AS; Dobyns, WB; Winder, TL; Strahl, S (2012). "ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome". Nat Genet. 44 (5): 575–80. doi:10.1038/ng.2252. PMC 3371168. PMID 22522420.