Laurie Glimcher

Laurie Glimcher
Rayuwa
Haihuwa	Tarayyar Amurka, 1951 (73/74 shekaru)
ƙasa	Tarayyar Amurka
Mazauni	Tarayyar Amurka
Karatu
Makaranta	Harvard Medical School (en) Radcliffe College (en)
Sana'a
Sana'a	immunologist (en) , physician-scientist (en) da researcher (en)
Mahalarcin World Economic Forum Annual Meeting 2018 (en)
Employers	Cornell Dana–Farber Cancer Institute (en) Jami'ar Harvard  (1972 -  1973) Massachusetts General Hospital (en)  (1976 -  1978) Brigham and Women's Hospital (en)  (1978 -  1979) Harvard Medical School (en)  (1982 -  1983) Massachusetts General Hospital (en)  (1982 -  1983) Brigham and Women's Hospital (en)  (1983 -  1986) Harvard T.H. Chan School of Public Health (en)  (1984 -  1986) Brigham and Women's Hospital (en)  (1986 -  1999) Harvard T.H. Chan School of Public Health (en)  (1986 -  1990) Harvard Medical School (en)  (1987 -  1991) Harvard Medical School (en)  (1991 -  2011) Harvard T.H. Chan School of Public Health (en)  (1991 -  2011) Brigham and Women's Hospital (en)  (1999 -  2012) Harvard T.H. Chan School of Public Health (en)  (2012 - NewYork–Presbyterian Hospital (en)  (2012 - Weill Cornell Medicine (en)  (2012 -
Kyaututtuka	gani L'Oréal-UNESCO Award For Women in Science  (2014) Kyautar FASEB a Kimiyya  (2001) Stanley J. Korsmeyer Award  (2001) Fellow of the American Academy of Arts and Sciences  (1996) American Association of Immunologists Lifetime Achievement Award  (2018) Vanderbilt Prize in Biomedical Science  (2013) Marion Spencer Fay Award  (2016) George M. Kober Medal  (2017) Fellow of the American Association for the Advancement of Science  (2009)
Mamba	National Academy of Sciences (en) American Academy of Arts and Sciences (en)

Laurie Hollis Glimcher (an haife ta a shekara ta 1951) likita ce kuma masanin kimiyya na Amurka kuma tsohon shugaban kasa kuma Shugaba na Cibiyar Ciwon daji ta Dana-Farber . An zabe ta a matsayin memba na American Philosophical Society a shekarar 2019.  Glimcher ya kasance a tsakiyar rikice-rikice da suka shafi Masu fafutukar kare hakkin dabbobi, biyan kuɗi na kamfanoni, da kuma mummunar hali na bincike. Binciken 2021 da ƙungiyar Boston Globe Spotlight ta yi ya nuna ayyukan Glimcher a kan allon kamfanoni da yawa, gami da Bristol Myers Squibb, GlaxoSmithKline, da Analog Devices. Bayan wannan binciken, Glimcher ta ci gaba da karɓar diyya a kan allon riba, yayin da ta ninka albashinta zuwa dala miliyan 4 a kowace shekara a Dana-Farber . A watan Oktoba na shekara ta 2024, Glimcher ya sauka a matsayin Shugaban kasa da Shugaba na Dana-Farber.

Ilimi

Glimcher ta kammala karatu daga Makarantar Winsor, makarantar masu zaman kansu ta mata a Boston, Massachusetts, a shekarar 1968. A shekara ta 1972, ta kammala digiri na biyu daga Kwalejin Radcliffe, sannan ta kammala karatu daga Makarantar Kiwon Lafiya ta Harvard a shekara ta 1976.

Ayyuka

Ta shiga kwamitin daraktocin Bristol-Myers Squibb a 1997 kuma ta yi ritaya daga kwamitin a 2017. Gidan bincikenta ya sami tallafi daga Merck & Co don aikin da aka mayar da hankali kan haɓaka sabbin hanyoyin warkewa don maganin osteoporosis a cikin 2008.

Daga 1991 zuwa 2012, Glimcher ya kasance Irene Heinz Given Farfesa na Immunology a Makarantar Kiwon Lafiyar Jama'a ta Harvard, farfesa a fannin kiwon lafiya a Makarantar Likita ta Harvard. A fannin kiwon lafiya, ƙwararre ce a cikin osteoporosis.

Daga 2012 zuwa 2016, Glimcher ya yi aiki a matsayin Stephen da Suzanne Weiss Dean na Kwalejin Kiwon Lafiya ta Weill Cornell da kuma Jami'ar Cornell Provost for Medical Affairs .

A watan Fabrairun 2016, an nada Laurie Glimcher a matsayin Shugaban kasa da Shugaba na Cibiyar Ciwon daji ta Dana-Farber. An yi la'akari da Glimcher don matsayin Dean na Makarantar Kiwon Lafiya ta Harvard amma ya juya matsayin don ya zama shugaban Cibiyar Ciwon daji ta Dana-Farber .

A Dana-Farber, Glimcher ya haɗu a kan bincike don neman hanyoyin yaki da ciwon daji daga cikin tsarin rigakafin ɗan adam. Cibiyar Ciwon daji ta Dana-Farber wata cibiya ce da ke da alaƙa da Harvard, kamar yadda a halin yanzu tana ɗaya daga cikin asibitocin koyarwa. Glimcher, wacce ita ce mace ta farko da ta kasance shugabar kowane makarantar likita a jihar New York, ta zama mace ta farko ta jagoranci Cibiyar Ciwon daji ta Dana-Farber.

A cikin 2017, ta shiga kwamitin GlaxoSmithKline . A cikin 2020, ta shiga kwamitin Analog Devices .

Bincike

Binciken Glimcher ya mayar da hankali kan Tsarin rigakafi; an san ta da aiki na farko tare da bambancin tantanin halitta na T, bincikenta cewa Schnurri-3 yana sarrafa osteoblasts wanda ya haifar da haɗin gwiwa tare da Merck & Co., da kuma binciken da XBP-1 ya taka a cikin lipogenesis da kuma amsawar furotin. Matsayin Glimcher ya taimaka wajen gano Schnurri-3 (Shn3 don takaice) babban furotin ne na zinc wanda ke da alaƙa da Drosophila. Shn mai iko ne kuma mai mahimmanci mai kula da tsarin ƙashi na manya. Binciken ta yana da tasiri ga fahimtar asma, HIV, cututtukan hanji, da osteoporosis, da kuma a kusa da 2016, akan maganin rigakafin ciwon daji.

Glimcher ta zama mai sha'awar rigakafi a lokacin shekara ta farko ta makarantar likita a Harvard. A can ta yi sha'awar dysregulation a cikin cututtukan rigakafi kuma, a cikin shekara ta huɗu a Harvard, ta gano furotin da aka sani da Nk1.1 (duba tantanin halitta mai kisan T), wanda ba da daɗewa ba ya zama sananne a duk faɗin ilimin rigakafi. Don wannan binciken, Glimcher ta zama mace ta farko da ta karbi kyautar Soma Weiss, girmamawa da mahaifinta ya samu shekaru 26 da suka gabata. A wannan lokacin, Glimcher ta yi aiki tare da mai ba da shawara Bill Paul, wanda ya ƙarfafa ta ta ci gaba da bincikenta da kanta bayan kammala makarantar likita.

Glimcher a halin yanzu tana jagorantar nata dakin gwaje-gwaje don bincike a cikin rigakafi. Tana da sha'awar nazarin alaƙar da ke tsakanin tsarin damuwa na ER a cikin neurons da aikin rigakafi da lalacewar neuro. Ayyukanta na baya sun haɗa da tsara aikin rigakafi kuma sun sauya zuwa osteobiology tare da mai da hankali kan Cutar ƙashi osteoporosis. Lab dinta na Harvard tana da kwangilar shekaru uku tare da Merck don maganin Fosamax, magani ga osteoporosis. Binciken Glimcher na yanzu yana neman amsa tambayar, "Ta yaya tsarin rigakafi da tsarin damuwa na ER ke tasiri ga ci gaban ciwon daji da ci gaba?"

Kyaututtuka da membobin

Glimcher ta sami lambar yabo ta L'Oréal-UNESCO don Mata a Kimiyya a shekarar 2014 saboda aikinta a fannin rigakafi da bincikenta game da kula da martani na rigakafi. A shekara ta 2014, ta sami lambar yabo ta Margaret Kripke Legend . Ta sami lambar yabo ta Steven C. Beering a shekarar 2015. A cikin 2018, ta sami lambar yabo ta American Association of Immunologists Lifetime Achievement Award .

An zabe ta a Kwalejin Kimiyya ta Kasa, Kwalejin Kiwon Lafiya ta Kasa, Cibiyar Fasaha da Kimiyya ta Amurka da Ƙungiyar Falsafa ta Amirka. Ita memba ce ta Kwalejin Fasaha da Kimiyya ta Amurka, Ƙungiyar Masu Kula da Kwararrun Kwararrun, Ƙungiyar Amurka don Binciken Asibiti, Ƙungiyar Likitoci ta Amurka, da Ƙungiyar Amurka ta Ci gaban Kimiyya. Ta kasance shugabar kungiyar American Association of Immunologists daga 2003 zuwa 2004.

A cikin 2020 an ba ta suna sabon memba na Kwamitin Ba da Shawara na Kimiyya na Tsayawa zuwa Ciwon daji .

Iyali

Glimcher 'yar Geraldine Lee (Bogolub) ce da Melvin J. Glimcher, wanda ya kasance majagaba a ci gaban gaɓoɓin wucin gadi yayin da yake shugaban sashen Orthopedics na Babban Asibitin Massachusetts. Iyalinta Yahudawa ne.

Glimcher ta bi sawun mahaifinta ta hanyar zama cikakken farfesa a Makarantar Kiwon Lafiya ta Harvard tana da shekaru 39; biyun sun zama abokan bincike.

Ta auri Gregory Petsko, Farfesa na Neurology a Cibiyar Ann Romney don Cututtukan Neurologic a Makarantar Kiwon Lafiya ta Harvard da Brigham da Asibitin Mata, wanda ya kasance darektan Cibiyar Binciken Kimiyya ta Rosenstiel da kuma shugaban ilimin kimiyyar halittu a Jami'ar Brandeis kafin ya koma Weill Cornell Medicine, inda ya zama darektan Helen da Robert Appel Alzheimer's Research Institute. Glimcher a baya ta auri Hugh Auchincloss, wanda shine babban mataimakin Dokta Anthony Fauci, kuma ya kasance shugaban Transplant Surgery a Brigham & Women's Hospital, kuma tare da shi ta haifi 'ya'ya uku, Kalah, Hugh da Jake Auchincloss.

'Yarta, Kalah Auchincloss, J.D., M.P.H., babban mataimakin shugaban bin ka'idoji ne kuma mataimakin babban lauya na Greenleaf Health kuma a baya ya kasance mataimakin Shugaban ma'aikata na kwamishinonin kula da abinci da magunguna guda biyu.

Ɗanta na fari, Dokta Hugh Glimcher Auchincloss, shi ma likita ne, a halin yanzu likitan zuciya ne a Babban Asibitin Massachusetts . Yaronta ƙarami, Jake Auchincloss, a halin yanzu shi ne wakilin Gundumar majalisa ta 4 ta Massachusetts.

Haɗin mata

Laurie Glimcher an dauke ta a matsayin mai gwagwarmayar kare hakkin mata a cikin al'ummar kimiyya ta yawancin takwarorinta.  Yayinda take a Harvard, ta hayar masu fasaha na dakin gwaje-gwaje tare da asusun bincikenta don tallafawa 'yan uwanta na postdoctoral bayan sun haifi jarirai don a ba su damar barin ta 6.  Wannan ya ci gaba da shiga cikin Glimcher tare da Cibiyoyin Lafiya na Kasa don ƙirƙirar irin wannan shirin tallafin postdoc kula da membobin iyali.

Glimcher ta yi aiki a cikin 2005 Larry Summers Task Force for Women in Science and Engineering, inda ta nuna takaici game da ci gaban mata a kimiyya.  Ta shiga wannan rundunar bayan an haifar da gardama lokacin da tsohon shugaban Harvard Larry Summers ya ba da shawarar cewa mata na iya yin kasa a kimiyya. Kodayake tana cikin kwamitin Larry Summers, Glimcher har yanzu ta yi imanin cewa har yanzu akwai ƙarin aiki da za a yi.  [ana buƙatar ƙaulin] An nakalto ta tana cewa: "Babu isasshen mata a manyan mukamai na jagoranci, lokaci. Ba ta sami mafi kyawun gaske ba tun lokacin da nake makarantar likita. " Bayan an nada ta a makarantar likita ta Cornell nan da nan ta yi canje-canje game da haƙƙin mata. Ta kafa hutun haihuwa da aka biya, ta kirkiro cibiyoyin kula da yara da kuma wani shirin tallafin postdoc ga masu kula da farko. Bayan isa Cornell akwai 0 daga cikin kujerun sashen asibiti 19 da mata suka cika; a yau akwai 2.

Rikici na NYBC

A cikin 2015, Masu fafutukar kare hakkin dabbobi sun yi niyya ga Glimcher kan zanga-zangar da suka yi na janye tallafi ga chimpanzees a Laberiya ta Cibiyar Jinin New York inda Glimcher ya kasance a cikin kwamitin na tsawon shekaru biyu.

Rahoton Boston Globe Spotlight da jayayya ta kwamitin kamfanoni

Lokacin da Glimcher ta fara aiki a Dana-Farber, ta ci gaba da aiki a kwamitin kamfanin magunguna na Bristol Myers Squibb duk da cewa kamfanin yana da hannu a yakin shari'a tare da Dana-Farbert game da haƙƙin haƙƙin mallaka da haƙƙin magani. Daga baya ta yi murabus daga wannan mukamin kuma ta shiga wani kwamitin samar da magunguna, a matsayin darektan GlaxoSmithKline . Matsayin Glimcher na biyu a matsayin Shugaba na Dana-Farber kuma a matsayin darektan allon kamfanoni da yawa an nuna shi a cikin labarin Boston Globe Spotlight "Shugabannin asibitin Boston sun haskaka a kan allon kamfanini a farashi da ya wuce matakin ƙasa, kuma ya haifar da kira da yawa tsakanin likitocin Harvard da ma'aikatan asibitin na Boston don hana shugabannin asibiti yin aiki a kan allunan kamfanoni.

Rikici game da sarrafa bayanai

A watan Janairun 2024 Glimcher na daga cikin masu bincike hudu a Dana-Farber da ake zargi da karkatar da bayanai a cikin takardun bincike. An yi amfani da hotuna a cikin takardun ta hanyar da ta ba da shawarar yunkurin da aka yi na yaudarar masu karatu. Ta yi ƙoƙari ta gyara wasu daga cikin bayanan, duk da haka an janye shida daga cikin waɗannan takardun har sai ana jiran sakamakon binciken yayin da ake gyara wasu.

Dubi kuma

• Cibiyar Ciwon daji ta Dana-Farber
• Rashin halayyar kimiyya

Haɗin waje

• Shafin gida na hukuma a Harvard