Nesfatin-1
 Nesfatin-1 | |
|---|---|
group or class of proteins (en)  | |
| Bayanai | |
| Ƙaramin ɓangare na |
neuropeptide (en) |
Nesfatin-1 shine neuropeptide wanda aka samar a cikin hypothalamus na dabbobi masu shayarwa . Yana shiga cikin ka'idar ajiyar yunwa da mai. [1] Ƙara nesfatin-1 a cikin hypothalamus yana taimakawa wajen rage yunwa, 'jin dadi', da yiwuwar asarar kitsen jiki da nauyi.
An gudanar da nazarin tasirin tasirin nesfatin-1 a cikin berayen inda abubuwan da aka sarrafa nesfatin-1 suka ci ƙasa da ƙasa, sun yi amfani da kitsen da aka adana da yawa kuma sun zama masu aiki. Nesfatin-1-induced hana ciyarwa na iya zama tsaka-tsaki ta hanyar hana ƙwayoyin cuta na orexigenic . [2] Bugu da ƙari, sunadaran suna motsa ƙwayar insulin daga ƙwayoyin beta na pancreatic na berayen da berayen. [3]
Biochemistry
[gyara sashe | gyara masomin]Nesfatin-1 shine polypeptide da aka sanya a cikin yankin N-terminal na precursor protein, Nucleobindin-2 ( NUCB2 ). Recombinant ɗan adam Nesfatin-1 furotin ne mai nauyin tara da dugo bakwai 9.7 kDa mai ɗauke da ragowar amino acid tamanin da biyu 82. [4] Nesfatin-1 yana bayyana a cikin hypothalamus, a wasu sassan kwakwalwa, da kuma a cikin tsibiran pancreatic, kwayoyin endocrin na ciki da adipocytes .
Nesfatin / NUCB2 an bayyana shi a cikin nau'i-nau'i masu sarrafa abinci kamar su paraventricular nucleus (PVN), arcuate nucleus (ARC), supraoptic nucleus (SON) na hypothalamus, yanki na hypothalamic na gefe (LHA), da zona incerta a cikin berayen. An kuma sami Nesfatin-1 immunoreactivity a cikin ƙananan ƙwayoyin kwakwalwa irin su tsakiya na sashin jiki (NTS) da Dorsal nucleus na jijiyar vagus .
Manazarta
[gyara sashe | gyara masomin]- ↑ Oh-i, Shinsuke; Shimizu, Hiroyuki; Satoh, Tetsurou; Okada, Shuichi; Adachi, Sachika; Inoue, Kinji; Eguchi, Hiroshi; Yamamoto, Masanori; et al. (2006). "Identification of nesfatin-1 as a satiety molecule in the hypothalamus". Nature. 443 (7112): 709–12. Bibcode:2006Natur.443..709O. doi:10.1038/nature05162. PMID 17036007. S2CID 4366701.
- ↑ Price, Christopher J.; Samson, Willis K.; Ferguson, Alastair V. (2008). "Nesfatin-1 inhibits NPY neurons in the arcuate nucleus". Brain Research. 1230: 99–106. doi:10.1016/j.brainres.2008.06.084. PMC 2590930. PMID 18625211.
- ↑ Gonzalez, R.; Reingold, B. K.; Gao, X.; Gaidhu, M. P.; Tsushima, R.; Unniappan, S. (2011). "Nesfatin-1 Exerts a Direct, Glucose-Dependent Insulinotropic Action on Mouse Islet Beta and MIN6 Cells". Journal of Endocrinology. 208 (3): R9–R16. doi:10.1530/JOE-10-0492. PMID 21224288.
- ↑ ProSci inc. "Nesfatin-1 Recombinant Protein". Archived from the original on 11 April 2013. Retrieved 21 March 2013.