Neurosyphilis
| Neurosyphilis | |
|---|---|
 | |
Description (en)  | |
| Iri | Tunjere, Dementia, bacterial infectious disease (en) , Yanayin da ba shi da kyau, neurodegeneration (en) Inflammatory disease of the central nervous system (en) |
| Field of study (en) | Cututtukan cututtuka (ƙwarewar kiwon lafiya) |
| Identifier (en) | |
| ICD-10 | A52.1 |
| ICD-9 | 090.40 da 094.1 |
| MedlinePlus | 000703 |
| eMedicine | 000703 |
| MeSH | D009494 |
Neurosyphilis shine kamuwa da tsarin juyayi na tsakiya ta hanyar Treponema pallidum, kwayar cuta da ke haifar da cutar syphilis da aka kamu da ita ta hanyar jima'i. A zamanin maganin rigakafi na zamani, an bayar da rahoton yawancin cututtukan neurosyphilis a cikin marasa lafiya masu dauke da kwayar cutar HIV.[1]
Neurosyphilis na iya gabatar da alamomi iri-iri waɗanda suka dogara da tsarin da ya shafi tsarin juyayi na tsakiya. Duk da yake neurosyphilis na farko sau da yawa ba shi da alamomi, meningitis shine mafi yawan bayyanar neurological na farkon matakin. Late neurosyphilis yawanci ya shafi kwakwalwa da spinal cord parenchyma, yana bayyana a matsayin Tabes dorsalis da general paresis. Syphilis na uku na iya haɗawa da tsarin gabobin daban-daban, kodayake neurosyphilis na iya faruwa a kowane mataki na kamuwa da cuta.[1]
Tarihin asibiti, gwajin jijiyoyin jiki, da kuma lumbar puncture don samun Ruwan ƙwaƙwalwa (CSF) don bincike suna da mahimmanci don gano neurosyphilis. Babu gwajin dakin gwaje-gwaje guda ɗaya don tabbatar da ganewar asali na neurosyphilis a duk lokuta.[2] Gwajin CSF-VDRL mai kyau a gaban alamun jijiyoyi ya isa don ganewar asali, amma ana iya buƙatar ƙarin gwaje-gwaje a wasu lokuta.[3]
Magani na yau da kullun shine maganin penicillin G na kwanaki 10 zuwa 14. Ya kamata a kimanta marasa lafiya da ke fama da neurosyphilis don cutar kanjamau, kuma ya kamata likitanci ya kimanta abokan aikinsu yadda ya kamata.[4]
Duk da yake ana rarraba matakai na syphilis a matsayin na farko, na biyu, latent, da na uku, neurosyphilis yawanci ana rarraba shi cikin farkon, matsakaici, da kuma ƙarshen matakai. Neurosyphilis na iya faruwa a kowane lokaci bayan kamuwa da cuta ta farko.[2]
Neurosyphilis na farko da na tsakiya
[gyara sashe | gyara masomin]Neurosyphilis na farko sau da yawa ba shi da alamun asibiti. Meningitis shine mafi yawan bayyanar cututtukan jijiyoyi a farkon syphilis, yawanci yana tasowa a cikin shekara guda na kamuwa da cuta ta farko.[1] Alamomin syphilitic meningitis suna kama da wasu nau'ikan meningitis, gami da ciwon kai, tsananin wuyansa, photophobia, rikicewa, ƙishirwa, da amai.[2] Rashin kumburi na meningeal na iya shafar jijiyoyin kwakwalwa, galibi jijiyoyin fuska, wanda ke nunawa a matsayin shanyayyen fuska.[1] Cerebral gummas, wanda ke haifar da lalacewar ƙwaƙwalwa daga syphilis, na iya haifar da alamun meningitis.[3]
Syphilis na meningovascular sau da yawa yana cikin matsakaicin matakin neurosyphilis, yawanci yana gabatar da shekaru 5 zuwa 12 bayan kamuwa da cuta.[1] Yana faruwa ne saboda kumburi na jijiyoyin jini da ke samar da tsarin juyayi na tsakiya, wanda ke haifar da mutuwar kwayar kwakwalwa da ake kira ischemic. Zai iya gabatar da shi azaman bugun jini ko rauni a kashin baya. Alamomi da alamomi sun bambanta da jijiyar jini da ta shafa. Tsakanin jijiyoyin kwakwalwa galibi suna shafar, suna haifar da alamomi iri-iri ciki har da rauni, asarar ji, karkatar da ido, da cutar hemineglect.[2]
Neurosyphilis na baya
[gyara sashe | gyara masomin]Parenchymal syphilis yana faruwa a ƙarshen matakin neurosyphilis, tare da matsakaicin gabatarwa da ke faruwa shekaru 15 zuwa 25 bayan kamuwa da cuta ta farko.[2] Wannan matakin cutar gabaɗaya a cikin nau'in Tabes dorsalis ko paresis gabaɗaya. Tabes dorsalis, wanda kuma ake kira locomotor ataxia, ya bayyana tarin alamun bayyanar cututtuka wanda ya haifar da tsarin lalacewa na ginshiƙan baya na kashin baya. Alamomin sun haɗa da ciwo, tafiya mai zurfi, paresthesias, ƙuƙwalwar hanji ko ƙuƙwalwa, asarar matsayi da ma'anar vibratory, ciwon gastrointestinal mai tsanani, haɗin Charcot, da ragewa. Ɗalibin Argyll Robertson, wanda shine yanayin da ɗalibai ba sa ƙuntata zuwa haske mai haske amma ƙuntata lokacin da suke mai da hankali kan wani abu mai kusa (haɗin kai), wani fasalin ne wanda zai iya kasancewa.[5]
Wani nau'in neurosyphilis na baya-bayan nan shine paresis na gaba ɗaya, wanda shine jinkirin lalacewa na kwakwalwa. Alamomin Neuropsychiatric na iya bayyana saboda lalacewar kwakwalwa gaba ɗaya. Wadannan alamun na iya sa ganewar asali ya fi wuya kuma yana iya haɗawa da alamun Rashin hankali, [6] mania, psychosis, baƙin ciki, da delirium. [7] Wadannan alamun na iya ci gaba har zuwa inda mai haƙuri ya zama a kan gado.[2][8]
Syphilis na ido da otosyphilis
[gyara sashe | gyara masomin]Kusan kowane bangare na ido na iya shiga cikin neurosyphilis, wanda ke haifar da syphilis na ido. Hanyar da aka fi sani da syphilis na ido ita ce uveitis . Sauran nau'ikan sun haɗa da episcleritis, vitritis, retinitis, papillitis, retinal detachment, da interstitial keratitis.[9][10] Marasa lafiya yawanci suna tare da mummunar hangen nesa.[11]
Otosyphilis yana nufin wani nau'in neurosyphilis wanda ke shafar jin" data-linkid="161" href="./Vestibulocochlear_nerve" id="mwvQ" rel="mw:WikiLink" title="Vestibulocochlear nerve">jijiyar vestibulocochlear, yana haifar da matsaloli tare da ji da daidaitawa. Alamun sun haɗa da asarar ji, tinnitus, Vertigo, da rashin daidaituwa.[12]
Syphilis na ido da otosyphilis na iya faruwa a kowane lokaci bayan kamuwa da cuta ta farko, kuma gabatarwarsa na iya haɗuwa da wasu alamun neurosyphilis.[2]
Manazarta
[gyara sashe | gyara masomin]- ↑ CDC (November 7, 2024). "National Overview of STIs in 2023". STI Statistics (in Turanci). Retrieved January 16, 2025.
- 1 2 3 4 5 Hamill, Matthew M; Ghanem, Khalil G; Tuddenham, Susan (May 15, 2024). "State-of-the-Art Review: Neurosyphilis". Clinical Infectious Diseases. 78 (5): e57–e68. doi:10.1093/cid/ciad437. ISSN 1058-4838. PMID 37593890 Check
|pmid=value (help). - ↑ "Syphilis - STI Treatment Guidelines". www.cdc.gov (in Turanci). October 3, 2024. Retrieved January 17, 2025.
- ↑ "Neurosyphilis, Ocular Syphilis, and Otosyphilis - STI Treatment Guidelines". www.cdc.gov (in Turanci). July 22, 2021. Retrieved January 17, 2025.
- ↑ Thompson, H. Stanley; Kardon, Randy H. (June 2006). "The Argyll Robertson pupil". Journal of Neuro-Ophthalmology. 26 (2): 134–138. doi:10.1097/01.wno.0000222971.09745.91. ISSN 1070-8022. PMID 16845316.
- ↑ Rao, Avinash; Khan, Ariba; Singh, Kanwardeep; Anderson, Debra L.; Malone, Michael L. (2015). "Neurosyphilis: An Uncommon Cause of Dementia". Journal of the American Geriatrics Society. 63 (8): 1710–1712. doi:10.1111/jgs.13571. PMID 26289700. S2CID 9393216.
- ↑ Kaur, Baneet; Khanna, Deepesh (September 7, 2023). "A Narrative Review of the Many Psychiatric Manifestations of Neurosyphilis: The Great Imitator". Cureus (in Turanci). 15 (9). doi:10.7759/cureus.44866. ISSN 2168-8184. PMC 10560128 Check
|pmc=value (help). PMID 37814742 Check|pmid=value (help). - ↑ "Neurosyphilis: Overview of Syphilis of the CNS, Pathophysiology of Syphilis, Epidemiology of Syphilis". July 19, 2021.
- ↑ Mehrabian S, Raycheva M, Traykova M, Stankova T, Penev L, Grigorova O, Traykov L (September 2012). "Neurosyphilis with dementia and bilateral hippocampal atrophy on brain magnetic resonance imaging". BMC Neurol. 12. doi:10.1186/1471-2377-12-96. PMC 3517431. PMID 22994551.
- ↑ Kennard, Christine (September 10, 2014). "Neurosyphilis". About.com. Archived from the original on October 23, 2014. Retrieved October 23, 2014.
- ↑ Vadboncoeur, Julie; Labbé, Annie-Claude; Fortin, Claude; Serhir, Bouchra; Rabia, Yasmine; Najem, Kinda; Jaworski, Laurence; Aubin, Marie-Josée (February 1, 2020). "Ocular syphilis: case series (2000–2015) from 2 tertiary care centres in Montreal, Canada". Canadian Journal of Ophthalmology (in English). 55 (1): 30–37. doi:10.1016/j.jcjo.2019.05.009. ISSN 0008-4182. PMID 31712031.CS1 maint: unrecognized language (link)
- ↑ Yimtae, Kwanchanok; Srirompotong, Somchai; Lertsukprasert, Krisna (2007). "Otosyphilis: A review of 85 cases". Otolaryngology–Head and Neck Surgery (in Turanci). 136 (1): 67–71. doi:10.1016/j.otohns.2006.08.026. ISSN 1097-6817. PMID 17210336.