Nutriepigenomics

Nutriepigenomics kuma ana kiransa sinadirai genomics, shine nazarin yadda abinci mai gina jiki da mahaɗan bioactive ke shafar lafiyar ɗan adam ta hanyar gyare-gyaren epigenetic, irin su DNA methylation, gyare-gyaren histone, da tsarin RNA mara coding. Yayin da nutrigenomics ke bincikar yadda abubuwan gina jiki da abinci ke tasiri ga maganganun kwayoyin halitta, nutriepigenomics musamman na nazarin yadda waɗannan abubuwan abinci ke haifar da canje-canjen epigenetic ba tare da canza tsarin DNA na asali ba. Yanzu akwai shaida mai yawa cewa rashin daidaituwa na abinci mai gina jiki-musamman a lokacin gestation, lactation, da farkon ci gaba - na iya haifar da sauye-sauye na epigenetic na dogon lokaci, ƙara haɗarin cututtuka marasa cututtuka, irin su kiba, cututtukan zuciya, ciwon sukari, hauhawar jini, da ciwon daji . Idan rikice-rikice na rayuwa sun faru a lokacin manyan windows na ci gaba, waɗannan gyare-gyare na epigenetic na iya haifar da canje-canje masu ɗorewa ga maganganun kwayoyin halitta, aikin nama, da rashin lafiyar cuta. ^[1]

Dubawa

Epigenetics yana da alaƙa da sauye-sauye na gado a cikin aikin kwayoyin halitta waɗanda ke faruwa ba tare da sauye-sauye a jerin DNA na farko ba. Manyan hanyoyin epigenetic guda biyu waɗanda ke cikin nutriepigenomics sune DNA methylation da gyaran tarihi . Methylation DNA a cikin yankuna masu tallata kwayoyin halitta yawanci yana haifar da yin shuru kuma yana rinjayar maganganun kwayoyin halitta. Duk da yake wannan nau'i na yin shiru na kwayoyin halitta yana da mahimmanci a cikin ci gaba da bambance-bambancen salula, DNA methylation na iya zama mai lalacewa kuma an danganta shi da matakai daban-daban na cututtuka, kamar ciwon daji. ^[2] Ƙungiyoyin methyl da aka yi amfani da su a cikin DNA methylation sau da yawa ana samo su ne daga tushen abinci, irin su folate da choline, kuma ya bayyana dalilin da yasa abinci na iya samun tasiri mai mahimmanci akan tsarin methylation da kuma maganganun kwayoyin halitta. ^[3] Hakanan za'a iya ƙarfafa yin shiru ta Gene ta hanyar ɗaukar histone deacetylases don rage kunna aikin rubutu. Sabanin haka, histone acetylation yana haifar da kunnawa na rubutu don ƙara yawan magana. Abubuwan da ake amfani da su na abinci na iya yin tasiri ga waɗannan abubuwan da suka faru na epigenetic, ta haka ne ke canza maganganun kwayoyin halitta da ayyuka masu tayar da hankali kamar su kula da ci, ma'auni na rayuwa da amfani da man fetur. ^[1]

Nutriepigenomics da haɓakawa

Lokacin haɓakawa wanda rashin daidaituwar abinci ya faru yana da matukar mahimmanci wajen tantance wane nau'in ƙwayoyin cuta da ke da alaƙa da cutar. Daban-daban gabobin suna da matakai masu mahimmanci na ci gaba, kuma lokacin da aka lalata su zai sa mutane su fuskanci wasu cututtuka. ^[4] gyare-gyaren Epigenetic da ke faruwa a lokacin ci gaba bazai iya bayyana ba har sai daga baya a rayuwa dangane da aikin kwayar halitta. ^[5] Yayin da yawancin nazarin ke haifar da lokacin haihuwa da kuma lokacin haihuwa a matsayin lokaci mai mahimmanci windows, wasu bincike sun nuna cewa cin abinci mai gina jiki a lokacin girma zai iya rinjayar epigenome.

Manazarta

1 2 Gallou-Kabani C, Vige A, Gross MS, Junien C (2007). "Nutri-epigenomics: Lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond". Clin Chem Lab Med. 45 (3): 321–7. doi:10.1515/CCLM.2007.081. PMID 17378726. S2CID 29084180.CS1 maint: multiple names: authors list (link) Cite error: Invalid <ref> tag; name "Gallou" defined multiple times with different content
↑ Berdasco M, Esteller M (2010). "Aberrant epigenetic landscape in cancer: How cellular identity goes awry". Dev Cell. 19 (5): 698–711. doi:10.1016/j.devcel.2010.10.005. PMID 21074720.
↑ Pozharny Y, Lambertini L, Clunie G, Ferrara L, Lee MJ (Mar 2010). "Epigenetics in women's health care". Mt Sinai J Med. 77 (2): 225–35. doi:10.1002/msj.20176. PMID 20309920.CS1 maint: multiple names: authors list (link)
↑ Hanley B, Dijane J, Fewtrell M, Grynberg A, Hummel S, Junien C, Koletzko B, Lewis S, Renz H, Symonds M, Gros M, Harthoorn L, Mace K, Samuels F, van Der Beek EM (Jul 2010). "Metabolic imprinting, programming and epigenetics - a review of present priorities and future opportunities". Br J Nutr. 104: S1–25. doi:10.1017/S0007114510003338. PMID 20929595.CS1 maint: multiple names: authors list (link)
↑ Pozharny Y, Lambertini L, Clunie G, Ferrara L, Lee MJ (Mar 2010). "Epigenetics in women's health care". Mt Sinai J Med. 77 (2): 225–35. doi:10.1002/msj.20176. PMID 20309920.CS1 maint: multiple names: authors list (link)

[Gallou-1] 1 2 Gallou-Kabani C, Vige A, Gross MS, Junien C (2007). "Nutri-epigenomics: Lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond". Clin Chem Lab Med. 45 (3): 321–7. doi:10.1515/CCLM.2007.081. PMID 17378726. S2CID 29084180.CS1 maint: multiple names: authors list (link) Cite error: Invalid <ref> tag; name "Gallou" defined multiple times with different content

[2] Berdasco M, Esteller M (2010). "Aberrant epigenetic landscape in cancer: How cellular identity goes awry". Dev Cell. 19 (5): 698–711. doi:10.1016/j.devcel.2010.10.005. PMID 21074720.

[Pozharny-3] Pozharny Y, Lambertini L, Clunie G, Ferrara L, Lee MJ (Mar 2010). "Epigenetics in women's health care". Mt Sinai J Med. 77 (2): 225–35. doi:10.1002/msj.20176. PMID 20309920.CS1 maint: multiple names: authors list (link)

[hanley2-4] Hanley B, Dijane J, Fewtrell M, Grynberg A, Hummel S, Junien C, Koletzko B, Lewis S, Renz H, Symonds M, Gros M, Harthoorn L, Mace K, Samuels F, van Der Beek EM (Jul 2010). "Metabolic imprinting, programming and epigenetics - a review of present priorities and future opportunities". Br J Nutr. 104: S1–25. doi:10.1017/S0007114510003338. PMID 20929595.CS1 maint: multiple names: authors list (link)

[Pozharny2-5] Pozharny Y, Lambertini L, Clunie G, Ferrara L, Lee MJ (Mar 2010). "Epigenetics in women's health care". Mt Sinai J Med. 77 (2): 225–35. doi:10.1002/msj.20176. PMID 20309920.CS1 maint: multiple names: authors list (link)

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