Rashin ƙarfi na lactase
 Rashin ƙarfi na lactase | |
|---|---|
adaptive trait (en)  | |
| Bayanai | |
| Has cause (en) |
adaptation (en) |
| Has characteristic (en) |
presence (en) da metabolism (en) |
| Characteristic of (en) |
adult human (en) |
| Hannun riga da |
lactose intolerance (en) |
Dagewar lactase ko haƙurin lactose shine ci gaba da aikin enzyme na lactase a cikin girma, yana ba da damar narkewar lactose a cikin madara . A yawancin dabbobi masu shayarwa, aikin enzyme yana raguwa sosai bayan yaye . [1] A cikin wasu mutane ko da yake, lactase dagewa ya samo asali ne kwanan nan [2] a matsayin daidaitawa ga cin abinci maras amfani da madara da kayan kiwo fiye da jariri. [3] Dagewar lactase yana da yawa a tsakanin mutanen arewacin Turai. A duk duniya, yawancin mutane suna lactase maras jurewa, [1] kuma suna shafar bambance-bambancen matakan rashin haƙuri na lactose a matsayin manya. Koyaya, dagewar lactase da rashin haƙuri na lactose na iya haɗuwa. [ bayani da ake bukata ]
Rarraba duniya na phenotype
[gyara sashe | gyara masomin]Rarraba yanayin lactase (LP) phenotype, ko ikon narkar da lactose zuwa girma, ba daidai ba ne a duniya. Matsakaicin tsayin daka na lactase suna da canji sosai. A cikin Turai, rarrabuwar lactase phenotype ne na asibiti, tare da mitoci daga 15-54% a kudu maso gabas zuwa 89-96% a arewa maso yamma. [4] Alal misali, kawai 17% na Helenawa da 14% na Sardinians ana annabta su mallaki wannan dabi'a, yayin da kusan 80% -100% na mutane a arewacin Turai da tsakiyar Turai an annabta su zama lactase naci. [5] Hakazalika, yawan lactase-juya shine asibiti a Indiya, nazarin 2011 na mutane 2,284 da ke nuna yawan LP a cikin al'ummar Ror, na Haryana, a Arewa maso Yamma, na 48.95%, ya ragu zuwa 1.5% a cikin Andamanese, na Kudu maso Gabas, na Arewa maso Gabas, da kuma Timan 0.8. [6] [7]
Manazarta
[gyara sashe | gyara masomin]- ↑ 1.0 1.1 Swallow, Dallas M. (December 2003). "Genetics of Lactase Persistence and Lactose Intolerance". Annual Review of Genetics. 37 (1): 197–219. doi:10.1146/annurev.genet.37.110801.143820. PMID 14616060.
- ↑ Bersaglieri, Todd; Sabeti, Pardis C.; Patterson, Nick; Vanderploeg, Trisha; Schaffner, Steve F.; Drake, Jared A.; Rhodes, Matthew; Reich, David E.; Hirschhorn, Joel N. (June 2004). "Genetic Signatures of Strong Recent Positive Selection at the Lactase Gene". The American Journal of Human Genetics. 74 (6): 1111–1120. doi:10.1086/421051. PMC 1182075. PMID 15114531.
- ↑ Cohen, Céleste E.; Swallow, Dallas M.; Walker, Catherine (2024). "The molecular basis of lactase persistence: Linking genetics and epigenetics". Annals of Human Genetics (in Turanci). 89 (5): 321–332. doi:10.1111/ahg.12575. ISSN 1469-1809. PMC 12336946 Check
|pmc=value (help). PMID 39171584 Check|pmid=value (help). - ↑ Gerbault, P.; Liebert, A.; Itan, Y.; Powell, A.; Currat, M.; Burger, J.; Swallow, D. M.; Thomas, M. G. (14 February 2011). "Evolution of lactase persistence: an example of human niche construction". Philosophical Transactions of the Royal Society B: Biological Sciences. 366 (1566): 863–877. doi:10.1098/rstb.2010.0268. PMC 3048992. PMID 21320900.
- ↑ Itan, Yuval; Jones, Bryony L; Ingram, Catherine JE; Swallow, Dallas M; Thomas, Mark G (2010). "A worldwide correlation of lactase persistence phenotype and genotypes". BMC Evolutionary Biology. 10 (1): 36. Bibcode:2010BMCEE..10...36I. doi:10.1186/1471-2148-10-36. PMC 2834688. PMID 20144208.
- ↑ Romero, Irene G (11 August 2011). "Herders of Indian and European Cattle Share Their Predominant Allele for Lactase Persistence". Molecular Biology and Evolution. 29 (1). Retrieved 2022-09-16.
- ↑ Tandon, R. K.; Joshi, Y. K.; Singh, D. S.; Narendranathan, M.; Balakrishnan, V.; Lal, K. (May 1981). "Lactose intolerance in North and South Indians". The American Journal of Clinical Nutrition. 34 (5): 943–946. doi:10.1093/ajcn/34.5.943. ISSN 0002-9165. PMID 7234720.