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Zena Werb

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Zena Werb
Rayuwa
Haihuwa Bergen-Belsen concentration camp (en) Fassara, 1945
ƙasa Tarayyar Amurka
Mazauni Saskatchewan (en) Fassara
Cambridge (en) Fassara
Mutuwa San Francisco, 16 ga Yuni, 2020
Karatu
Makaranta University of Toronto (en) Fassara
The Rockefeller University (en) Fassara
Thesis director Zanvil A. Cohn (en) Fassara
Harsuna Turanci
Sana'a
Sana'a cell biologist (en) Fassara da university teacher (en) Fassara
Employers University of California, San Francisco (en) Fassara
Strangeways Research Laboratory (en) Fassara
Kyaututtuka
Mamba National Academy of Sciences (en) Fassara
American Academy of Arts and Sciences (en) Fassara

Zena Werb (24 Maris 1945 - 16 Yuni 2020) farfesa ce kuma Mataimakin Shugaban Anatomy a Jami'ar California, San Francisco .  Ta kuma kasance co-shugaban Ciwon daji, rigakafi, da Shirin Microenvironment a Cibiyar Ciwon daji ta Hellen Diller Family kuma memba na Kwamitin Zartarwa na Cibiyar Bincike ta Sabre-Sandler Asthma a UCSF . [1][2] Binciken da ta yi ya mayar da hankali kan siffofin microenvironment da ke kewaye da sel, tare da sha'awa ta musamman ga matrix na extracellular da rawar da enzymes na protease ke takawa a cikin siginar sel.[3][4]

Rayuwa ta farko da ilimi

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An haifi Zena Werb a Jamus a 1945 a sansanin Bergen-Belsen (KZ Bergen-B Nielsen), 'yan makonni kafin a saki sansanin. Iyayenta biyu, wadanda suka kasance 'yan Poland-Yahudawa, sun tsira daga yakin, tare da mahaifinta ya gudu zuwa Italiya. Iyalinta sun sake haduwa a sansanin 'yan gudun hijira a Italiya a 1947; [5] sun yi hijira zuwa Kanada a 1948, inda Werb ta girma a gona a Ontario. [6][7] Kodayake mahaifinta a baya masanin lissafi ne, ya zama manomi.[5]

Werb ta sami B.Sc. a Biochemistry daga Jami'ar Toronto a shekarar 1966, bayan ta canza babban nata daga geophysics bayan an gaya mata cewa babu masauki ga mata a wani filin wasa.[6][8] Ta sami Ph.D. a cikin Cell Biology daga Jami'ar Rockefeller a 1971, tana aiki a ƙarƙashin kulawar Zanvil Cohn a kan wata takarda mai taken "Dynamics of macrophage membrane cholesterol".[9] Bayan kammala karatunta ta yi aiki a Cibiyar Nazarin Strangeways a Cambridge, Burtaniya a matsayin abokin karatun postdoctoral tare da John T. Dingle daga 1971 zuwa 1973 kuma a matsayin mai bincike daga 1973 zuwa 1975. [2][7][10]

Ayyukan ilimi

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Werb ta shafe shekara guda a matsayin mataimakiyar farfesa a makarantar likitancin Dartmouth a New Hampshire kafin ta koma Jami'ar California, San Francisco a 1976, inda ta zama cikakken farfesa a 1983. [2] [7][10] Ta yi aiki a matsayin shugabar American Society for Cell Biology a shekara ta 2004.[11] Ta yi magana game da darajar sabbatical na ilimi, kuma a cikin 2007 ta yi sabbatical a Cibiyar Max Planck ta hanyar Kyautar Bincike ta Alexander von Humboldt.[12][13]

Werb ta rubuta kuma ta ba da tambayoyi game da abubuwan da ta samu a matsayin mace a kimiyya, tana kwatanta yanayin da ta horar da ita a matsayin mai nuna bambancin jinsi kuma tana lura da cewa, duk da ci gaban wakilcin mata a cikin kimiyya tun lokacin da ta horarwa, jima'i "ya tafi karkashin kasa" [6] kuma ƙarancin wakilcin mata masu matsayi na sama ya kasance matsala.[14][15]

Ta kasance memba na Kwamitin Edita don Ci gaban Cell .

Kyaututtuka da girmamawa

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  • Kyautar FASEB Excellence in Science daga Tarayyar Ƙungiyoyin Amirka don Nazarin Halitta (1966) [13]
  • Guggenheim Fellowship (1985-6) [7]
  • Ƙungiyar Amurka don Binciken Ciwon daji Mata a Binciken Cutar Charlotte Friend Memorial Lectureship (2001) [16]
  • UCSF Kwalejin Bincike na Shekara (2001) [17]
  • Fellow na Kwalejin Fasaha da Kimiyya ta Amurka (2003) [13]
  • E.B. Wilson Medal daga American Society for Cell Biology (2007) [18]
  • Kyautar Rayuwa ta Rayuwa daga Mata a cikin Kwayoyin Kwayoyin Kwayar halitta, ƙungiyar ASCB (2010) [19]
  • memba na Kwalejin Kimiyya ta Kasa ta Amurka (2010) [13]
  • Nasarar Rayuwa ta UCSF a Kyautar Jagora (2015) [20]

Bincike

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Kungiyar bincike ta Werb tana nazarin tasirin sel na microenvironment na matrix na extracellular da sassanta, musamman matrix metalloproteinases. Har ila yau, ƙungiyar tana bincika rawar da waɗannan tasirin ke takawa a kan matakai na halitta kamar su tsufa da ƙwayoyin cuta, wanda suke amfani da ciwon nono a cikin beraye a matsayin abin koyi.[3][8] Ayyukanta na kafa rawar da ECM ke takawa a cikin siginar tantanin halitta na yau da kullun da kuma ci gaban ciwon daji an san shi da tasiri sosai.[7][21]

Manazarta

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  1. ↑ "About Cancer, Immunity, and Microenvironment". University of California, San Francisco. Retrieved 4 July 2015.
  2. ↑ 2.0 2.1 2.2 "Zena Werb, Ph.D." University of California, San Francisco. Archived from the original on 5 July 2015. Retrieved 4 July 2015.
  3. ↑ 3.0 3.1 "Research". Werb Lab. University of California, San Francisco. Retrieved 4 July 2015.
  4. ↑ Littlepage, Laurie E.; Ewald, Andrew J.; Alexander, Caroline; Casbon, Amy-Jo; Lu, Pengfei; Kessenbrock, Kai; Provot, Sylvain; Phillips, Joanna J.; Kouros-Mehr, Hosein; Chan, Matilda; Welm, Bryan (2020-08-10). "Zena Werb (1945–2020)". Developmental Cell (in Turanci). 54 (3): 299–301. doi:10.1016/j.devcel.2020.07.012. ISSN 1534-5807.
  5. ↑ 5.0 5.1 Egeblad, Mikala (2021-03-04). "Zena Werb (1945–2020): Matrix Metalloproteinases, Microenvironments, and Mentoring". Annual Review of Cancer Biology (in Turanci). 5 (1): 1–16. doi:10.1146/annurev-cancerbio-081320-114426. ISSN 2472-3428.
  6. ↑ 6.0 6.1 6.2 Watt, F. M. (22 February 2004). "Zena Werb". Journal of Cell Science. 117 (6): 803–804. doi:10.1242/jcs.01031. PMID 14963020.
  7. ↑ 7.0 7.1 7.2 7.3 7.4 "ASCB Profiles" (PDF). American Society for Cell Biology. Archived from the original (PDF) on 5 July 2015. Retrieved 4 July 2015.
  8. ↑ 8.0 8.1 Kain, K. H. (10 August 2010). "The extracellular matrix and disease: an interview with Zena Werb". Disease Models & Mechanisms. 3 (9–10): 513–516. doi:10.1242/dmm.006338. PMID 20699476. S2CID 116090690.
  9. ↑ As cited in: Werb, Zena; Cohn, Zanvil A. (1971). "Cholesterol metabolism in the macrophage. I. The regulation of cholesterol exchange". The Journal of Experimental Medicine. 134 (6): 1545–69. doi:10.1084/jem.134.6.1545. PMC 2139099. PMID 5126640.
  10. ↑ 10.0 10.1 "Zena Werb". Werb Lab. University of California, San Francisco. Archived from the original on 5 July 2015. Retrieved 4 July 2015.
  11. ↑ "ASCB Presidents". American Society for Cell Biology. Retrieved 4 July 2015.
  12. ↑ Hoag, Hannah (16 August 2007). "The seven-year itch". Nature. 448 (7155): 834–835. doi:10.1038/nj7155-834a.
  13. ↑ 13.0 13.1 13.2 13.3 "Zena Werb, Ph.D." UCSF Helen Diller Family Comprehensive Cancer Center. Retrieved 4 July 2015.
  14. ↑ Neugebauer, Karla M. (2006). "Keeping Tabs on the Women: Life Scientists in Europe". PLOS Biology. 4 (4): e97. doi:10.1371/journal.pbio.0040097. PMC 1435409. PMID 16602822.
  15. ↑ Werb, Z. (15 November 2010). "The Joy of a Career in Cell Biology". Molecular Biology of the Cell. 21 (22): 3764–3766. doi:10.1091/mbc.E10-05-0413. PMC 2982121. PMID 21079003.
  16. ↑ "AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship: Past Recipients". American Association for Cancer Research (AACR) (in Turanci). Retrieved 2020-02-09.
  17. ↑ "Faculty Research Lecture in Basic Science 44th | UCSF Academic Senate". senate.ucsf.edu. Retrieved 2020-02-09.
  18. ↑ "E.B. Wilson Medal". ASCB (in Turanci). Retrieved 2020-02-09.
  19. ↑ "WICB Awards". American Society for Cell Biology. Archived from the original on 4 March 2016. Retrieved 4 July 2015.
  20. ↑ "Zena Werb receives UCSF 2015 Mentoring Award". Department of Anatomy. University of California, San Francisco. 10 April 2015. Archived from the original on 5 July 2015. Retrieved 4 July 2015.
  21. ↑ Egeblad, M; Werb, Z (March 2002). "New functions for the matrix metalloproteinases in cancer progression". Nature Reviews. Cancer. 2 (3): 161–74. doi:10.1038/nrc745. PMID 11990853. S2CID 7990149.

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