Fayil:Serpin mechanism.png

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English: Serine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the catalytic triad (red) to form an acyl-enzyme intermediate. The intermediate is typically resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX​)
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Masomi Aikin na
Marubucin Thomas Shafee

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na yanzu09:56, 22 Disamba 2015Wadar sufa ta zubin 09:56, 22 Disamba 20151,800 × 1,488 (513 KB)Evolution and evolvabilityHigher resolution
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