Chronic myelogenous leukemia

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Chronic myelogenous leukemia
Bcrablmet.jpg
Description (en) Fassara
Iri myeloid leukemia (en) Fassara, chronic leukemia (en) Fassara
disease (individual) (en) Fassara
Specialty (en) Fassara oncology (en) Fassara
Treatment (en) Fassara
Magani uracil mustard (en) Fassara, busulfan (en) Fassara, idarubicin (en) Fassara, (RS)-cyclophosphamide (en) Fassara, plicamycin (en) Fassara, hydroxyurea (en) Fassara, thioguanine hydrate (en) Fassara, imatinib mesylate (en) Fassara da pipobroman (en) Fassara
Identifier (en) Fassara
ICD-10-CM C91.1
ICD-9-CM 205.1
ICD-10 C92.1
ICD-O: 9875/3 da 9863/3
OMIM 608232
DiseasesDB 2659
MedlinePlus 000570
eMedicine 000570
MeSH D015464
Disease Ontology ID DOID:8552

Ciwon daji na myelogenous na yau da kullun (CML), wanda kuma aka sani da cutar sankarar myeloid na yau da kullun, nau'in ciwon daji ne wanda ke tattare da fararen jini, musamman granulocytes.[1] Dukan jini da kasusuwan kasusuwa suna shafar.[1] A lokacin ganewar asali kusan rabin mutane ba su da alamun cutar.[1] Alamun farko na iya haɗawa da gajiya da ciwon ciki na sama na hagu saboda girma mai girma.[1] Daga baya alamomin na iya haɗawa da ciwon kai, ciwon kashi, zazzaɓi, da kuma ƙararrakin ƙwayoyin lymph.[1] Matsalolin na iya haɗawa da zubar jini da priapism.[1]

An fayyace ƴan abubuwan haɗari, kodayake ya fi zama ruwan dare tsakanin waɗanda suka tsira daga bam ɗin atomic.[1] Fiye da 90% na waɗanda abin ya shafa suna da chromosome na Philadelphia wanda ke samuwa saboda fassarar chromosomal.[1] Wani nau'in neoplasm na myeloproliferative ne.[1] Ana zargin ganewar asali ne bisa cikakken adadin ƙwayoyin jini (CBC) kuma an tabbatar da shi ta hanyar gwajin cytogenetic.[1] Ana iya raba cutar zuwa matakai uku, na yau da kullun, hanzari, da fashewa.[2]

Jiyya yana tare da ƙungiyar magunguna da aka sani da masu hana tyrosine-kinase (TKIs).[1] Waɗannan sun haɗa da imatinib, bosutinib, dasatinib, da nilotinib.[1] Sauran zaɓuɓɓukan na iya haɗawa da dashen kasusuwa da omacetaxine.[1] Tare da samar da TKIs adadin tsira na shekaru biyar ya karu daga 33% zuwa fiye da 70%.[1][3]

Kimanin kashi 0.9 cikin 100,000 na mutanen da suka kamu da cutar a kowace shekara.[1] Yawan shekarun ganewar asali yana kusa da shekaru 56.[1] A kasashen yammacin duniya, yana da kashi 20% na cutar sankarar bargo.[4] Yana da wuya a cikin yara.[2] An ƙaddara tushen dalilin a cikin 1960 Ta Nowell da Hungerford.[5]

Manazarta[gyara sashe | Gyara masomin]

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Eden, RE; Coviello, JM (January 2020). "Chronic Myelogenous Leukemia". PMID 30285354. Cite journal requires |journal= (help)
  2. 2.0 2.1 "Chronic Myelogenous Leukemia Treatment (PDQ®)–Patient Version - National Cancer Institute". www.cancer.gov (in Turanci). 11 May 2020. Retrieved 9 January 2021.
  3. "Chronic Myeloid Leukemia - Cancer Stat Facts". SEER (in Turanci). Retrieved 9 January 2021.
  4. "Chronic Myelogenous Leukemia (CML): Practice Essentials, Background, Pathophysiology". 26 August 2020. Retrieved 9 January 2021.
  5. Soiffer, Robert J. (2004). Stem Cell Transplantation for Hematologic Malignancies (in Turanci). Springer Science & Business Media. p. 25. ISBN 978-1-59259-733-8.