Michael Z. Lin
 Michael Z. Lin | |
|---|---|
| Rayuwa | |
| Haihuwa | Taipei, 1973 (50/51 shekaru) |
| Karatu | |
| Makaranta |
UCLA David Geffen School of Medicine (en)  (15 ga Yuni, 1994 - 15 ga Yuni, 2004) Doctor of Medicine (en) |
| Sana'a | |
| Sana'a |
researcher (en) , biologist (en) da chemist (en) |
| Employers | Jami'ar Stanford (1 Mayu 2009 - |
Michael Z. Lin (an haife shi a shekara ta alif 1973) a Taipei, a ƙasar Taiwan) ɗan Taiwan-Ba-Amurke masanin ilimin halittu ne kuma injiniyan halittu. Shi mataimakin Farfesa ne na Neurobiology da Bioengineering a Jami'ar Stanford. An fi saninsa da aikin injiniyanci na gani da ido da sunadarai masu sinadarai.
Ilimi da aiki
[gyara sashe | gyara masomin]Lin ya kammala karatu daga Jami'ar Harvard a 1994 tare da digiri a cikin ilimin kimiyyar halittu summa cum laude.[1] Daga baya ya horar da shi a matsayin dalibi na PhD yana nazarin fassarar siginar neuronal tare da Michael E. Greenberg a Makarantar Kiwon Lafiya ta Harvard, ya kammala karatunsa a 2002,[2] kuma ya sami MD a UCLA a 2004. [3] Daga nan Lin ya yi bincike na gaba da digiri tare da Chemistry Nobel Prize Laureate Roger Y. Tsien a UCSD.[4] Tun 2009, ya kasance memba na baiwa a Makarantar Magunguna ta Jami'ar Stanford.
Bincike
[gyara sashe | gyara masomin]A lokacin horo na postdoctoral tare da Roger Y. Tsin, Lin ya haɓaka ingantattun sunadaran sunadaran ja[5] [6] da channelrhodopsins, [7] kuma ya fara yin amfani da magungunan miyagun ƙwayoyi don gyare-gyaren furotin a cikin hanyar lakabin furotin TimeSTAMP. Rukunin Lin a Jami'ar Stanford sun ƙera sunadaran sunadaran tare da sabbin ayyuka don optogenetics, chemogenetics, da ilimin halitta na roba. Fitattun abubuwan ƙirƙira sun haɗa da:
- Red fluorescent da sunadaran bioluminescent [8] [9]
- Sunadaran da za'a iya canzawa ta gani ta amfani da ingin ingin sunadaran furotin mai kyalli [10] [11]
- Iyali mai nuna alamar wutar lantarki ta asali ta ASAP [12] [13]
- Sarrafa sinadarai na bayanin furotin ta hanyar ƙwayoyin cuta na RNA [14] [15]
- Sunadaran roba waɗanda ke sake dawo da siginar cutar kansa zuwa kunnawar warkewa [16] [17]
- SARS-CoV-2 protease inhibitors dangane da gyara HCV protease inhibitors [18]
Kyaututtuka da karramawa
[gyara sashe | gyara masomin]- Kudin hannun jari Burroughs Wellcome Fund Kyauta a Kimiyyar Kiwon Lafiya (2007) [19]
- Kyautar Majagaba ta Cibiyar Kiwon Lafiya ta Ƙasa (2013)
- Masanin Gidauniyar Rita Allen (2016) [20]
- Ƙungiyar Hoto Kwayoyin Halitta ta Duniya Roger Tsien Awardee don Ƙwarewa a Ilimin Sinadarai (2019) [21]
Manazarta
[gyara sashe | gyara masomin]- ↑ "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.
- ↑ "Chemistry Tree - Michael Z. Lin". academictree.org.
- ↑ "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.
- ↑ "Chemistry Tree - Michael Z. Lin". academictree.org.
- ↑ Shaner, N. C.; Lin, M. Z.; McKeown, M. R.; Steinbach, P. A.; Hazelwood, K. L.; Davidson, M. W.; Tsien, R. Y. (2008). "Improving the photostability of bright monomeric orange and red fluorescent proteins". Nature Methods. 5 (6): 545–51. doi:10.1038/nmeth.1209. PMC 2853173. PMID 18454154
- ↑ Empty citation (help)
- ↑ Lin, J. Y.; Lin, M. Z.; Steinbach, P.; Tsien, R. Y. (2009). "Characterization of engineered channelrhodopsin variants with improved properties and kinetics". Biophysical Journal. 96 (5): 1803–14. Bibcode:2009BpJ....96.1803L. doi:10.1016/j.bpj.2008.11.034. PMC 2717302. PMID 19254539
- ↑ Chu, J.; Oh, Y.; Sens, A.; Ataie, N.; Dana, H.; MacKlin, J. J.; Laviv, T.; Welf, E. S.; Dean, K. M.; Zhang, F.; Kim, B. B.; Tang, C. T.; Hu, M.; Baird, M. A.; Davidson, M. W.; Kay, M. A.; Fiolka, R.; Yasuda, R.; Kim, D. S.; Ng, H. L.; Lin, M. Z. (2016). "A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo". Nature Biotechnology. 34 (7): 760–7. doi:10.1038/nbt.3550. PMC 4942401. PMID 27240196
- ↑ Gitig, Diana (9 November 2016). "Watching a cell cycle". Ars Technica
- ↑ "Phosphorylation at the Flick of a Switch". The Scientist Magazine
- ↑ Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577
- ↑ Vogt, Nina (January 2020). "RAMPing up voltage indicator imaging". Nature Methods. 17 (1): 25. doi:10.1038/s41592-019-0720-4. PMID 31907465. S2CID 209897141
- ↑ Villette, V; Chavarha, M; Dimov, IK; Bradley, J; Pradhan, L; Mathieu, B; Evans, SW; Chamberland, S; Shi, D; Yang, R; Kim, BB; Ayon, A; Jalil, A; St-Pierre, F; Schnitzer, MJ; Bi, G; Toth, K; Ding, J; Dieudonné, S; Lin, MZ (12 December 2019). "Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice". Cell. 179 (7): 1590–1608.e23. doi:10.1016/j.cell.2019.11.004. PMC 6941988. PMID 31835034
- ↑ Chung, H. K.; Jacobs, C. L.; Huo, Y.; Yang, J.; Krumm, S. A.; Plemper, R. K.; Tsien, R. Y.; Lin, M. Z. (2015). "Tunable and reversible drug control of protein production via a self-excising degron". Nature Chemical Biology. 11 (9): 713–20. doi:10.1038/nchembio.1869. PMC 4543534. PMID 26214256
- ↑ Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496
- ↑ Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496
- ↑ Chung, HK; Zou, X; Bajar, BT; Brand, VR; Huo, Y; Alcudia, JF; Ferrell JE, Jr; Lin, MZ (3 May 2019). "A compact synthetic pathway rewires cancer signaling to therapeutic effector release". Science. 364 (6439): eaat6982. doi:10.1126/science.aat6982. PMC 7053279. PMID 31048459
- ↑ Westberg, Michael; Su, Yichi; Zou, Xinzhi; Ning, Lin; Hurst, Brett; Tarbet, Bart; Lin, Michael Z. (2020-09-16). "Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases". bioRxiv: 2020.09.15.275891. doi:10.1101/2020.09.15.275891. S2CID 221823586
- ↑ "2011-2007 Awardees | Burroughs Wellcome Fund". www.bwfund.org
- ↑ "Michael Lin". Rita Allen Foundation.
- ↑ "World Molecular Imaging Society Announces Early Stage Awardees for 2019". World Molecular Imaging Society. 12 September 2019.