James Ferrell
 James Ferrell | |
|---|---|
 | |
| Rayuwa | |
| Haihuwa |
Gary (en)  , 3 Nuwamba, 1955 (68 shekaru) |
| ƙasa | Tarayyar Amurka |
| Mazauni |
Chicago Pittsburgh (en) |
| Karatu | |
| Makaranta |
Jami'ar Stanford 1984) Doctor of Philosophy (en) : kimiya Jami'ar Stanford 1986) Doctor of Medicine (en) Williams College (en) 1976) : physics (en) , kimiya, LissafiUniversity of California, Berkeley (en) |
| Sana'a | |
| Sana'a |
biologist (en) |
| Employers |
University of Wisconsin–Madison (en) (1990 - Stanford University School of Medicine (en) (1992 - |
| web.stanford.edu… | |
James Ellsworth Ferrell (an haife shi Nuwamba 3, 1955) masanin ilimin halittu ne na kasar Amurka. Shi Farfesa ne na sanin sinadarai da kuma ilimin sanin halittu a Makarantar Magunguna ta Jami'ar Stanford . Ya kasance Shugaban Sashen Kimiyya da Tsarin Halittu tun farkonsa a 2006 har ya zuwazuwa 2011.
Ilimi
[gyara sashe | gyara masomin]Ferrell ya kasance dalibi na farko a Kwalejin Williams, wanda ya fi girma a Physics, Chemistry, da Lissafi, kuma ya kammala karatunsa a 1976. Ya samu Ph.D. digiri a Chemistry daga Jami'ar Stanford a 1984 don aiki a dakin gwaje-gwaje na Wray H. Huestis kan kula da siffar jan cell, kuma ya sami digiri na MD daga Stanford a 1986. Ya gudanar da aikin postdoctoral akan watsa siginar a cikin dakin gwaje-gwaje na G. Steven Martin a UC Berkeley
Bincike
[gyara sashe | gyara masomin]Ta hanyar nazarin Xenopus laevis oocyte maturation, Ferrell ya nuna yadda sauye-sauyen sauye-sauye a cikin progesterone mai haɓakawa ya canza zuwa wanda ba zai iya canzawa ba, duk-ko-babu canje-canje a cikin ayyukan MAP kinase, aikin kinase na dogara cyclin, da kuma rabo na cell. [1] [2] [3] [4] [5] Waɗannan karatun sun taimaka nuna yadda rashin jin daɗi, kyakkyawar amsawa, da bistability na iya ba da damar sel su canza tsakanin jihohi masu hankali. [6]
Aiki na gaba daga dakin gwaje-gwaje na Ferrell [7] da sauransu [8] sun nuna cewa canjin tantanin halitta tsakanin interphase da mitosis ana daidaita shi ta hanyar sauya bistable, kuma cewa zagayowar tantanin halitta na Xenopus na farko yana aiki kamar oscillator na shakatawa. [9] [10] [11] Waɗannan binciken sun taimaka tabbatar da tsinkayar ka'idar tun farko da nazarin ƙirar ƙira. [12] [13]
Kwanan nan dakin binciken Ferrell ya nuna cewa yanayin mitotic na iya yaduwa ta hanyar Xenopus cytoplasm ta hanyar raƙuman ruwa, raƙuman ruwa na ayyukan Cdk1 waɗanda ke yaduwa da sauri fiye da ƙwayoyin furotin na Cdk1 na iya yaduwa. [14] [15] [16] Sun kuma nuna cewa apoptosis yana yaduwa ta hanyar cytoplasm ta hanyar raƙuman ruwa; "gudun mutuwa" yana kusan 2 mm a kowace awa. [17] [18]
Manazarta
[gyara sashe | gyara masomin]- ↑ "Department renamed to reflect shift in focus". Stanford University. 2006-10-18. Retrieved 2015-03-06.
- ↑ Huang, C. Y; Ferrell Jr, J. E (1996). "Ultrasensitivity in the mitogen-activated protein kinase cascade". Proceedings of the National Academy of Sciences of the United States of America. 93 (19): 10078–83. Bibcode:1996PNAS...9310078H. doi:10.1073/pnas.93.19.10078. PMC 38339. PMID 8816754
- ↑ Huang, C. Y; Ferrell Jr, J. E (1996). "Ultrasensitivity in the mitogen-activated protein kinase cascade". Proceedings of the National Academy of Sciences of the United States of America. 93 (19): 10078–83. Bibcode:1996PNAS...9310078H. doi:10.1073/pnas.93.19.10078. PMC 38339. PMID 8816754
- ↑ Ferrell Jr, J. E; Machleder, E. M (1998). "The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes". Science. 280 (5365): 895–8. Bibcode:1998Sci...280..895F
- ↑ Xiong, Wen; Ferrell, James E (2003). "A positive-feedback-based bistable 'memory module' that governs a cell fate decision". Nature. 426 (6965): 460–5. Bibcode:2003Natur.426..460X. doi:10.1038/nature02089. PMID 14647386. S2CID 4396489
- ↑ Sible, Jill C (2003). "Cell biology: Thanks for the memory". Nature. 426 (6965): 392–3. Bibcode:2003Natur.426..392S. doi:10.1038/426392a. PMID 14647363
- ↑ Ferrell, James E. (2002-04-01). "Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability". Current Opinion in Cell Biology. 14 (2): 140–148. doi:10.1016/S0955-0674(02)00314-9. ISSN 0955-0674. PMID 11891111
- ↑ Pomerening, Joseph R; Sontag, Eduardo D; Ferrell, James E (2003). "Building a cell cycle oscillator: Hysteresis and bistability in the activation of Cdc2". Nature Cell Biology. 5 (4): 346–51. doi:10.1038/ncb954. PMID 12629549. S2CID 11047458
- ↑ Sha, W; Moore, J; Chen, K; Lassaletta, A. D; Yi, C.-S; Tyson, J. J; Sible, J. C (2002). "Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts". Proceedings of the National Academy of Sciences. 100 (3): 975–80. doi:10.1073/pnas.0235349100. PMC 298711. PMID 12509509
- ↑ Pomerening, Joseph R; Kim, Sun Young; Ferrell, James E (2005). "Systems-Level Dissection of the Cell-Cycle Oscillator: Bypassing Positive Feedback Produces Damped Oscillations". Cell. 122 (4): 565–78. doi:10.1016/j.cell.2005.06.016. PMID 16122424
- ↑ Cross, Frederick R; Siggia, Eric D (2005). "Shake It, Don't Break It: Positive Feedback and the Evolution of Oscillator Design". Developmental Cell. 9 (3): 309–10. doi:10.1016/j.devcel.2005.08.006. PMID 16139219
- ↑ Adler, E. M; Gough, N. R; Ray, L. B (2005). "2005: Signaling Breakthroughs of the Year". Science Signaling. 2006 (316): eg1. doi:10.1126/stke.3162006eg1. PMID 16391177. S2CID 45634327
- ↑ Novak, B; Tyson, J. J (1993). "Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos". Journal of Cell Science. 106 (4): 1153–68. doi:10.1242/jcs.106.4.1153. PMID 8126097
- ↑ Goldbeter, A (1993). "Modeling the mitotic oscillator driving the cell division cycle". Comments on Theoretical Biology. 3: 75–107
- ↑ Chang, Jeremy B; Ferrell Jr, James E (2013). "Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle". Nature. 500 (7464): 603–7. Bibcode:2013Natur.500..603C. doi:10.1038/nature12321. PMC 3758429. PMID 23863935
- ↑ Ishihara, K; Nguyen, P. A; Wuhr, M; Groen, A. C; Field, C. M; Mitchison, T. J (2014). "Organization of early frog embryos by chemical waves emanating from centrosomes". Philosophical Transactions of the Royal Society B: Biological Sciences. 369 (1650): 20130454. doi:10.1098/rstb.2013.0454. PMC 4113098. PMID 25047608
- ↑ Berndt, J. D; Gough, N. R (2014). "2013: Signaling Breakthroughs of the Year". Science Signaling. 7 (307): eg1. doi:10.1126/scisignal.2005013. PMID 24399293. S2CID 40864652
- ↑ Cheng, Xianrui; Ferrell, James E. (2018-08-10). "Apoptosis propagates through the cytoplasm as trigger waves". Science. 361 (6402): 607–612. Bibcode:2018Sci...361..607C. doi:10.1126/science.aah4065. ISSN 0036-8075. PMC 6263143. PMID 30093599