Ciwon daji na mahaifa
Kwayar cutar kansa ta mahaifa DataBase (CCDB) wani bayanan bayanai ne na kwayoyin halitta da ke da hannu a cikin Ciwon daji na mahaifa.[1] Cibiyar Bayanai ta Ciwon Cutar Cutar Ciki ita ce bayanan farko da aka tsara da hannu.[2] Bayanan bayanan yana aiki ne a matsayin mahalli ga likitoci da masu bincike don bincika bayanan asali da kuma bayanan ci gaba game da kwayoyin halitta waɗanda ke bambanta cikin ciwon daji na mahaifa.[3] Akwai kwayoyin halitta 537 da aka tsara a cikin CCBD. Kwayoyin halittar da aka tsara bisa ga polymorphism, methylation, fadada kwayoyin halitta, da canji a yadda aka bayyana kwayar halitta. Masu binciken kimiyya sun bincika bayanan da suka kwatanta ƙwayoyin mahaifa na yau da kullun tare da ƙwayoyin cuta masu cutarwa waɗanda aka yi amfani da su don nazarin nau'ikan kwayoyin halitta daban-daban waɗanda ke haifar da ciwon daji na mahaifa. Daga cikin mata 500,000 da suka mutu a cikin mahaifa, mafi yawansu sun fito ne daga kasashe masu tasowa da kuma matakin zamantakewa da tattalin arziki a kasashe masu ci gaba. An tsara CCBD don gabatar da bayanai waɗanda za su sami sababbin magunguna don haifar da ciwon daji a cikin yawan mata.[4]
Abubuwan da aka haɗa
[gyara sashe | gyara masomin]- miRNA na kwayar halitta
- rahoton PubMed na kwayar halitta
- mai karɓar bakuncin da kuma kwayar halitta
- wuri da kuma canjin furotin
- furci ko canjin kwayar halitta.
Amfani da shi
[gyara sashe | gyara masomin]Bayanan ciwon daji na mahaifa ya ƙunshi bayanan da masu amfani (masu bincike da likitoci) na tsarin zasu iya ganowa idan kwayar halitta ta haifar da bayyanar ciwon daji. Likitoci da masu bincike za su iya tattara bayanai yayin da yake da alaƙa da kwayoyin halitta waɗanda zasu iya bambanta zuwa ciwon daji na mahaifa. Akwai nau'o'i da yawa na ciwon daji na mahaifa wanda ke hypermethylate.[5] CCDB tana ba da bayanai masu dacewa game da wane kwayar halitta mai hana kumburi ta yi shiru game da bayyanar kwayar halitta na ciwon daji. [ana buƙatar ƙa'ida][ana buƙatar hujja][<span title="This claim needs references to reliable sources. (May 2021)">citation needed</span>]
Samun dama
[gyara sashe | gyara masomin]Clinicians ko masu bincike na iya bincika kwayar halitta ta amfani da lambar chromosome, I.D. kwayar halitta, ko sunan kwayar halitta.[6] Masu bincike na iya ƙara bayani game da kwayoyin halitta waɗanda ke da lambar don ciwon daji na mahaifa, amma kafin a kara bayanan zuwa bayanan, dole ne masana kimiyya su tabbatar da shi.[7]
Dubi kuma
[gyara sashe | gyara masomin]Manazarta
[gyara sashe | gyara masomin]- ↑ Agarwal, Subhash M; Raghav Dhwani; Singh Harinder; Raghava G P S (Jan 2011). "CCDB: a curated database of genes involved in cervix cancer". Nucleic Acids Res. England. 39 (Database issue): D975–9. doi:10.1093/nar/gkq1024. PMC 3013652. PMID 21045064.
- ↑ Agarwal, S M; Agarwal, S.M.; Raghav, D.; Singh, H.; Raghava, G. P. S. (2010). "CCDB: a curated database of genes involved in Cervix Cancer Nucleic Acids Res". GPS.
- ↑ Hakim, AA; Lin PS; Wilczynski S; Nguyen K; Lynes B; Wakabayashi MT. (2010). "Indications and efficacy of the human papillomavirus vaccine". Curr. Treat Options Oncol. 8 (6): 393–401. doi:10.1007/s11864-007-0050-0. PMID 18172770. S2CID 207322276.
- ↑ Phongsavan, Keokedthong; Phengsavanh, Alongkone; Wahlström, Rolf; Marions, Lena (June 2010). "Women's Perception of Cervical Cancer and Its Prevention in Rural Laos". International Journal of Gynecologic Cancer. 20 (5): 821–826. doi:10.1111/IGC.0b013e3181daaefb. PMID 20606529. S2CID 27963086.
- ↑ Hagemann T, T.; Bozanovic, T; Hooper, S; Ljubic, A; Slettenaar, VI; Wilson, JL; Singh, N; Gayther, SA; et al. (2007). "Molecular profiling of cervical cancer progression". Br. J. Cancer. 96 (2): 321–328. doi:10.1038/sj.bjc.6603543. PMC 2360010. PMID 17242701.
- ↑ Sayers, EW; Barrett T; Benson DA; Bolton E; Bryant SH; Canese K; Chetvernin V; Church DM; Dicuccio M; et al. (2010). "Database resources of the National Center for Biotechnology Information". Nucleic Acids Res. 38 (Database issue): D5–D16. doi:10.1093/nar/gkp967. PMC 2808881. PMID 19910364.
- ↑ Ongenaert, M; Van Neste L; De Meyer T; Menschaert G; Bekaert S; Van Criekinge W (2008). "PubMeth: a cancer methylation database combining text-mining and expert annotation". Nucleic Acids Res. 36 (Database issue): D842–D846. doi:10.1093/nar/gkm788. PMC 2238841. PMID 17932060.